about
Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line.Loss of centrioles causes chromosomal instability in vertebrate somatic cells.Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.Chromosome damage and progression into and through mitosis in vertebrates.Centriole separation in DNA damage-induced centrosome amplification.Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells.Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesisAnalysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores.Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells.Roles of vertebrate Smc5 in sister chromatid cohesion and homologous recombinational repair.Centrin2 regulates CP110 removal in primary cilium formation.Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis.Replication stress is a potent driver of functional decline in ageing haematopoietic stem cellsDNA damage induces Chk1-dependent centrosome amplification.Ciliary abnormalities in senescent human fibroblasts impair proliferative capacityC-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis.Calcium-binding capacity of centrin2 is required for linear POC5 assembly but not for nucleotide excision repair.Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells.Proteomics Analysis with a Nano Random Forest Approach Reveals Novel Functional Interactions Regulated by SMC Complexes on Mitotic Chromosomes.Increased sister chromatid cohesion and DNA damage response factor localization at an enzyme-induced DNA double-strand break in vertebrate cells.Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification.The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability.Centrosomes in the DNA damage response--the hub outside the centre.Opposing effects of pericentrin and microcephalin on the pericentriolar material regulate CHK1 activation in the DNA damage response.MCPH1/BRIT1 limits ionizing radiation-induced centrosome amplification.CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity.Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line.Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization.Centrobin controls primary ciliogenesis in vertebrates.Protein stability versus function: effects of destabilizing missense mutations onBRCA1DNA repair activityAltered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive functionKIFC3 directs a centrosome cohesive forceDifferential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repairMolecular causes of primary microcephaly and related diseases: a report from the UNIA Workshop
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description
researcher ORCID ID = 0000-0003-2401-7029
@en
wetenschapper
@nl
name
Ciaran G Morrison
@ast
Ciaran G Morrison
@en
Ciaran G Morrison
@nl
type
label
Ciaran G Morrison
@ast
Ciaran G Morrison
@en
Ciaran G Morrison
@nl
prefLabel
Ciaran G Morrison
@ast
Ciaran G Morrison
@en
Ciaran G Morrison
@nl
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0000-0003-2401-7029