about
Heritable transmission of stress resistance by high dietary glucose in Caenorhabditis elegansIntegration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicityExpression of human Bcl-xL (Ser49) and (Ser62) mutants in Caenorhabditis elegans causes germline defects and aneuploidy.The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington's diseaseInsulin signaling in the aging of healthy and proteotoxically stressed mechanosensory neuronsLarge-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons.Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.TDP-43 toxicity proceeds via calcium dysregulation and necrosis in aging Caenorhabditis elegans motor neurons.Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis.Worming forward: amyotrophic lateral sclerosis toxicity mechanisms and genetic interactions in Caenorhabditis elegans.Fishing for causes and cures of motor neuron disorders.Fragile lifespan expansion by dietary mitohormesis in C. elegans.Simple animal models for amyotrophic lateral sclerosis drug discovery.Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models.Glucose delays age-dependent proteotoxicity.Deciphering genetic interactions between ALS genes using C. elegans.Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo.[Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons].Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity.Rescue of ATXN3 neuronal toxicity in Caenorhabditiselegans by chemical modification of endoplasmic reticulum stress.Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons.Maple Syrup Decreases TDP-43 Proteotoxicity in a Caenorhabditis elegans Model of Amyotrophic Lateral Sclerosis (ALS).[Stress-induced propagation of neurodegeneration by wild-type proteins in simple models of ALS]
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description
researcher ORCID ID = 0000-0002-3333-2445
@en
wetenschapper
@nl
name
Alex J Parker
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Alex J Parker
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Alex J Parker
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type
label
Alex J Parker
@ast
Alex J Parker
@en
Alex J Parker
@nl
prefLabel
Alex J Parker
@ast
Alex J Parker
@en
Alex J Parker
@nl
P31
P496
0000-0002-3333-2445