about
Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2DIFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production.Identification of an intestinal heme transporterADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugationImaging immune surveillance by T cells and NK cells.The protean immune cell synapse: a supramolecular structure with many functions.Control of immune responses by trafficking cell surface proteins, vesicles and lipid rafts to and from the immunological synapse.OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.Membranous structures transfer cell surface proteins across NK cell immune synapses.The size of the synaptic cleft and distinct distributions of filamentous actin, ezrin, CD43, and CD45 at activating and inhibitory human NK cell immune synapses.Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells.Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis.Protocol for the induction of arthritis in C57BL/6 mice.The activating NKG2D ligand MHC class I-related chain A transfers from target cells to NK cells in a manner that allows functional consequences.Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis.Target Identification Using Chemical ProbesInhibitory Receptor Signals Suppress Ligation-Induced Recruitment of NKG2D to GM1-Rich Membrane Domains at the Human NK Cell Immune SynapseANTI-CD3 therapy expands the numbers of CD4+ and CD8+ Treg cells and induces sustained amelioration of collagen-induced arthritisTNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophagesInvestigating the Role of Toll-Like Receptors in Models of ArthritisAnti-Tumour Necrosis Factor Therapy for Dupuytren's Disease: A Randomised Dose Response Proof of Concept Phase 2a Clinical TrialSingle cell force profiling of human myofibroblasts reveals a biophysical spectrum of cell statesTNF receptor 2 signaling prevents DNA methylation at the Foxp3 promoter and prevents pathogenic conversion of regulatory T cellsIdentification of TNFR2 and IL-33 as therapeutic targets in localized fibrosisA genetics-led approach defines the drug target landscape of 30 immune-related traitsErratumCellular census of human fibrosis defines functionally distinct stromal cell types and states
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P50
description
Forscher
@de
chercheur
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hulumtuese
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investigador
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researcher
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հետազոտող
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研究者
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name
Fiona E McCann
@ast
Fiona E McCann
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Fiona E McCann
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Fiona E McCann
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type
label
Fiona E McCann
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Fiona E McCann
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Fiona E McCann
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Fiona E McCann
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prefLabel
Fiona E McCann
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Fiona E McCann
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Fiona E McCann
@es
Fiona E McCann
@nl
P21
P31
P496
0000-0001-8151-8781