about
IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancerTo fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and deathUbiquitin-Mediated Regulation of Cell Death, Inflammation, and Defense of HomeostasisInhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammationCARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migrationTranscription factor AP-2 essential for cranial closure and craniofacial developmentEssential versus accessory aspects of cell death: recommendations of the NCCD 2015.MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation.Analysis of Apoptosis and Necroptosis by Fluorescence-Activated Cell Sorting.An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways.DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cellsThe unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles.Alternative mRNAs encode multiple isoforms of transcription factor AP-2 during murine embryogenesis.Lucifer's labyrinth--ten years of path finding in cell death.Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes.Signal Integration by the IκB Protein Pickle Shapes Drosophila Innate Host Defense.Inactivation of effector caspases through nondegradative polyubiquitylation.Ubiquitin-mediated regulation of apoptosis.Inhibitor of apoptosis proteins in Drosophila: gatekeepers of death.A tangled web of ubiquitin chains: breaking news in TNF-R1 signaling.IAPs: guardians of RIPK1Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors.Time-Lapse Imaging of Cell Death.Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival.The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection.Time-lapse imaging of necrosis.The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesisUbiquitin-mediated regulation of RhoGTPase signalling: IAPs and HACE1 enter the fray.RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements.IAP-antagonists exhibit non-redundant modes of action through differential DIAP1 binding.Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling.PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling.IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms.Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling.Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.
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description
researcher ORCID ID = 0000-0003-2760-6523
@en
name
P Meier
@ast
P Meier
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Pascal Meier
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P Meier
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P Meier
@nl
Pascal Meier
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P Meier
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P Meier
@ast
P Meier
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Pascal Meier
@en
P21
P31
P496
0000-0003-2760-6523