about
Early innate responses to pathogens: pattern recognition by unconventional human T-cellsA molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cellsDeterminants of gliadin-specific T cell selection in celiac diseaseInterferon gamma: a master regulator of atherosclerosis.The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro.Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy.MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usageProteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components.Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load.A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years.Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation.CD8+ TCR Bias and Immunodominance in HIV-1 Infection.Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamicsβ-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure.Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells.Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance.Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages.IL-33 reduces macrophage foam cell formation.Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity.Complex T-cell receptor repertoire dynamics underlie the CD8+ T-cell response to HIV-1VDJdb: a curated database of T-cell receptor sequences with known antigen specificity.Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response.The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate.Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions.Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors.T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.Exploring the pre-immune landscape of antigen-specific T cellsTRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis.SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissuesPrimary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T CellsHuman CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells
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description
Forscher
@de
chercheur
@fr
investigador
@es
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
研究者
@zh
name
James E McLaren
@ast
James E McLaren
@en
James E McLaren
@es
James E McLaren
@nl
type
label
James E McLaren
@ast
James E McLaren
@en
James E McLaren
@es
James E McLaren
@nl
prefLabel
James E McLaren
@ast
James E McLaren
@en
James E McLaren
@es
James E McLaren
@nl
P1153
12806134000
P31
P496
0000-0002-7021-5934