about
Functional Heterogeneity in CD4(+) T Cell Responses Against a Bacterial PathogenPositive and negative selection of the T cell repertoire: what thymocytes see (and don't see)The ability to rearrange dual TCRs enhances positive selection, leading to increased Allo- and Autoreactive T cell repertoires.c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells.Both positive and negative effects on immune responses by expression of a second class II MHC molecule.Self-pMHCII complexes are variably expressed in the thymus and periphery independent of mRNA expression but dependent on the activation state of the APCsColitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane VesiclesClec16a is Critical for Autolysosome Function and Purkinje Cell SurvivalDual receptor T cells mediate pathologic alloreactivity in patients with acute graft-versus-host diseaseT cell immunodominance is dictated by the positively selecting self-peptideIntrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC.L-Myc expression by dendritic cells is required for optimal T-cell primingSelf-peptides in TCR repertoire selection and peripheral T cell function.The TCR Takes Some Immune Responsibility.LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens.Loss of Navβ4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance
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P50
description
Forscher
@de
chercheur
@fr
investigador
@es
researcher
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wetenschapper
@nl
հետազոտող
@hy
研究者
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name
Paul M Allen
@ast
Paul M Allen
@en
Paul M Allen
@es
Paul M Allen
@nl
type
label
Paul M Allen
@ast
Paul M Allen
@en
Paul M Allen
@es
Paul M Allen
@nl
prefLabel
Paul M Allen
@ast
Paul M Allen
@en
Paul M Allen
@es
Paul M Allen
@nl
P31
P496
0000-0003-3796-6047