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The role of a topologically conserved isoleucine in glutathione transferase structure, stability and functionArginine 15 stabilizes an S(N)Ar reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1Role of individual histidines in the pH-dependent global stability of human chloride intracellular channel 1Refined crystal structure of porcine class Pi glutathione S-transferase (pGST P1-1) at 2.1 A resolutionStructure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymesOverexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) ProteinPlasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashionX-ray crystal structures of cytosolic glutathione S-transferases. Implications for protein architecture, substrate recognition and catalytic functionDouble mutation at the subunit interface of glutathione transferase rGSTM1-1 results in a stable, folded monomer.The isomerization of Δ5-androstene-3,17-dione by the human glutathione transferase A3-3 proceeds via a conjugated heteroannular diene intermediateAnalysis of the levels of conservation of the J domain among the various types of DnaJ-like proteins.Polymyxin B inhibits the chaperone activity of Plasmodium falciparum Hsp70.S-nitrosation of glutathione transferase p1-1 is controlled by the conformation of a dynamic active site helix.Active-site mutations in the South african human immunodeficiency virus type 1 subtype C protease have a significant impact on clinical inhibitor binding: kinetic and thermodynamic study.Structural dynamics of soluble chloride intracellular channel protein CLIC1 examined by amide hydrogen-deuterium exchange mass spectrometry.The hydrophobic lock-and-key intersubunit motif of glutathione transferase A1-1: implications for catalysis, ligandin function and stability.Energetics of Glutathione Binding to Human Eukaryotic Elongation Factor 1 Gamma: Isothermal Titration Calorimetry and Molecular Dynamics Studies.The Lyssavirus glycoprotein: A key to cross-immunity.The intersubunit lock-and-key motif in human glutathione transferase A1-1: role of the key residues Met51 and Phe52 in function and dimer stabilityAmide hydrogen exchange in HIV-1 subtype B and C proteases--insights into reduced drug susceptibility and dimer stability.F99 is critical for dimerization and activation of South African HIV-1 subtype C protease.Aflatoxin B1 and sulphobromophthalein binding to the dimeric human glutathione S-transferase A1-1: a fluorescence spectroscopic analysis.Phosphorylation- and nucleotide-binding-induced changes to the stability and hydrogen exchange patterns of JNK1β1 provide insight into its mechanisms of activation.Thermodynamics of the ligandin function of human class Alpha glutathione transferase A1-1: energetics of organic anion ligand binding.A topologically conserved aliphatic residue in alpha-helix 6 stabilizes the hydrophobic core in domain II of glutathione transferases and is a structural determinant for the unfolding pathway.Electrostatic interactions affecting the active site of class sigma glutathione S-transferase.The cochaperone murine stress-inducible protein 1: overexpression, purification, and characterization.A Lys-Trp cation-π interaction mediates the dimerization and function of the chloride intracellular channel protein 1 transmembrane domain.Energetics of ligand binding to human glutathione transferase A1-1: Tyr-9 associated localisation of the C-terminal helix is ligand-dependent.Molecular recognition at the dimer interface of a class mu glutathione transferase: role of a hydrophobic interaction motif in dimer stability and protein function.Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance.Residue 219 impacts on the dynamics of the C-terminal region in glutathione transferase A1-1: implications for stability and catalytic and ligandin functions.JNK1β1 is phosphorylated during expression in E. coli and in vitro by MKK4 at three identical novel sites.Role of arginine 29 and glutamic acid 81 interactions in the conformational stability of human chloride intracellular channel 1.Purification and characterisation of recombinant human eukaryotic elongation factor 1 gamma.A conserved N-capping motif contributes significantly to the stabilization and dynamics of the C-terminal region of class Alpha glutathione S-transferases.The FOXP2 forkhead domain binds to a variety of DNA sequences with different rates and affinities.Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study.A conserved cationic motif enhances membrane binding and insertion of the chloride intracellular channel protein 1 transmembrane domain.
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P50
description
researcher ORCID ID = 0000-0003-1455-7769
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wetenschapper
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name
Heini W Dirr
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Heini W Dirr
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Heini W Dirr
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Heini W Dirr
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type
label
Heini W Dirr
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Heini W Dirr
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Heini W Dirr
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Heini W Dirr
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Heini W Dirr
@ast
Heini W Dirr
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Heini W Dirr
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Heini W Dirr
@nl
P1153
7006834313
P31
P496
0000-0003-1455-7769