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Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current InhibitionHuman-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop.Population of computational rabbit-specific ventricular action potential models for investigating sources of variability in cellular repolarisationUp-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthaseThe Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study.The role of transmural ventricular heterogeneities in cardiac vulnerability to electric shocks.Reentry in survived subepicardium coupled to depolarized and inexcitable midmyocardium: insights into arrhythmogenesis in ischemia phase 1BArrhythmogenesis in the heart: Multiscale modeling of the effects of defibrillation shocks and the role of electrophysiological heterogeneityGeneration of histo-anatomically representative models of the individual heart: tools and applicationDifferences between left and right ventricular chamber geometry affect cardiac vulnerability to electric shocks.Synthesis of voltage-sensitive optical signals: application to panoramic optical mapping.In vivo human left-to-right ventricular differences in rate adaptation transiently increase pro-arrhythmic risk following rate accelerationmRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: a population-based simulation study.Application of stochastic phenomenological modelling to cell-to-cell and beat-to-beat electrophysiological variability in cardiac tissueInter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation.Rabbit-specific ventricular model of cardiac electrophysiological function including specialized conduction systemA multiscale investigation of repolarization variability and its role in cardiac arrhythmogenesis.The role of photon scattering in optical signal distortion during arrhythmia and defibrillation.In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular CardiomyocytesWhat have we learned from mathematical models of defibrillation and postshock arrhythmogenesis? Application of bidomain simulationsModeling cardiac ischemiaVariability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm.Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology.Photon scattering effects in optical mapping of propagation and arrhythmogenesis in the heartHuman ventricular activation sequence and the simulation of the electrocardiographic QRS complex and its variability in healthy and intraventricular block conditions.Functional identification of islet cell types by electrophysiological fingerprinting.The systems biology approach to drug development: application to toxicity assessment of cardiac drugs.Bridging experiments, models and simulations: an integrative approach to validation in computational cardiac electrophysiology.Na/K pump regulation of cardiac repolarization: insights from a systems biology approach.β-Adrenergic receptor stimulation inhibits proarrhythmic alternans in postinfarction border zone cardiomyocytes: a computational analysis.Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia.Electrophysiological properties of computational human ventricular cell action potential models under acute ischemic conditions.Inference of intramural wavefront orientation from optical recordings in realistic whole-heart models.Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve.Balance between sodium and calcium currents underlying chronic atrial fibrillation termination: An in silico intersubject variability study.ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk.Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual Action Potential Variability.Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic CardiotoxicityMechanistic investigation into the arrhythmogenic role of transmural heterogeneities in regional ischaemia phase 1A.Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy.
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description
Professor of Computational Medicine at the University of Oxford
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wetenschapper
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name
B Rodriguez
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B Rodriguez
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Blanca Rodriguez
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type
label
B Rodriguez
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B Rodriguez
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Blanca Rodriguez
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altLabel
B Rodriguez
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prefLabel
B Rodriguez
@ast
B Rodriguez
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Blanca Rodriguez
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P1960
qYidL6sAAAAJ
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P2456
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P496
0000-0001-6361-3339