about
3D Mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle cryo-EM.A Novel Lid-Covering Peptide Inhibitor of Nicotinic Acetylcholine Receptors Derived from αD-Conotoxin GeXXA.Identification of a Novel O-Conotoxin Reveals an Unusual and Potent Inhibitor of the Human α9α10 Nicotinic Acetylcholine ReceptorCyclization of the intrinsically disordered α1S dihydropyridine receptor II-III loop enhances secondary structure and in vitro function.Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif.Molecular recognition of the disordered dihydropyridine receptor II-III loop by a conserved spry domain of the type 1 ryanodine receptor.Ubiquitous SPRY domains and their role in the skeletal type ryanodine receptor.α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors.α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition.Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins.Assembly, trafficking and function of α1β2γ2 GABAA receptors are regulated by N-terminal regions, in a subunit-specific manner.Gabapentin Modulates HCN4 Channel Voltage-Dependence.Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors.Exploring the Relationship between Nicotinic Acetylcholine Receptor Ligand Size, Efficiency, Efficacy, and C-Loop Opening.Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer.In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens.Targeting of N-Type Calcium Channels via GABAB-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic ActivityStructure–Activity Studies Reveal the Molecular Basis for GABAB-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1Molecular Determinants Conferring the Stoichiometric-Dependent Activity of α-Conotoxins at the Human α9α10 Nicotinic Acetylcholine Receptor SubtypeRole of the ρ1 GABA(C) receptor N-terminus in assembly, trafficking and functionStoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIBMolecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptorFulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors
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description
researcher ORCID ID = 0000-0001-8961-7194
@en
wetenschapper
@nl
name
Han-Shen Tae
@ast
Han-Shen Tae
@en
Han-Shen Tae
@es
Han-Shen Tae
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type
label
Han-Shen Tae
@ast
Han-Shen Tae
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Han-Shen Tae
@es
Han-Shen Tae
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prefLabel
Han-Shen Tae
@ast
Han-Shen Tae
@en
Han-Shen Tae
@es
Han-Shen Tae
@nl
P1153
56548329400
57194579029
P31
P496
0000-0001-8961-7194