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Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice.The adult livers of immunodeficient mice support human hematopoiesis: evidence for a hepatic mast cell population that develops early in human ontogeny.In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.A basolateral sorting motif in the MICA cytoplasmic tail.Hepatocytes buried in the cirrhotic livers of patients with biliary atresia proliferate and function in the livers of urokinase-type plasminogen activator-NOG mice.A versatile technique for the in vivo imaging of human tumor xenografts using near-infrared fluorochrome-conjugated macromolecule probes.The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice.Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice.Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice.Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice.The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice.Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment.Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry.Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology.In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes.Predominant development of mature and functional human NK cells in a novel human IL-2-producing transgenic NOG mouse.Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor.Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.Study on AAV-mediated gene therapy for diabetes in humanized liver mouse to predict efficacy in humans.Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver.Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling.Emergence of hepatitis C virus NS5A L31V plus Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice.Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling.Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.Mutation analysis of vinyl carbamate or urethane induced lung tumors in rasH2 transgenic mice.Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes.Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse.Human hepatocytes depletion in the presence of HIV-1 infection in dual reconstituted humanized mice.Chimeric Mice with Humanized Liver as a Model for Testing Organophosphate and Carbamate Pesticide Exposure.Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice.Expression profiling of placentomegaly associated with nuclear transplantation of mouse ES cells.Sox17 is Essential for Proper Formation of the Marginal Zone of Extraembryonic Endoderm Adjacent to a Developing Mouse Placental Disk.Innate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity.Formation of the accumulative human metabolite and human-specific glutathione conjugate of diclofenac in TK-NOG chimeric mice with humanized livers.Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanised liversImmunological responses against hepatitis B virus in human peripheral blood mononuclear cell-engrafted miceCombinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver miceDecreased expression of liver glutathione peroxidase in Long-Evans cinnamon mutant rats predisposed to hepatitis and hepatoma
P50
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P50
description
researcher ORCID ID = 0000-0002-3706-2454
@en
wetenschapper
@nl
name
Hiroshi Suemizu
@ast
Hiroshi Suemizu
@en
Hiroshi Suemizu
@es
Hiroshi Suemizu
@nl
type
label
Hiroshi Suemizu
@ast
Hiroshi Suemizu
@en
Hiroshi Suemizu
@es
Hiroshi Suemizu
@nl
prefLabel
Hiroshi Suemizu
@ast
Hiroshi Suemizu
@en
Hiroshi Suemizu
@es
Hiroshi Suemizu
@nl
P31
P496
0000-0002-3706-2454