about
Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stressHTS compatible assay for antioxidative agents using primary cultured hepatocytes.Cytotoxicity of advanced glycation endproducts in human micro- and astroglial cell lines depends on the degree of protein glycation.Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells.Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner.Metabolic response of glioblastoma cells associated with glucose withdrawal and pyruvate substitution as revealed by GC-MS.Inhibition of tumour cell growth by carnosine: some possible mechanisms.Identification of a cis-acting element and a novel trans-acting factor of the glutamine synthetase gene in liver cells.Modulation of GLO1 Expression Affects Malignant Properties of Cells.The antineoplastic effect of carnosine is accompanied by induction of PDK4 and can be mimicked by L-histidine.Hedgehog signaling in glioblastoma multiforme.Carnosine inhibits ATP production in cells from malignant glioma.Inflammatory cytokines increase extracellular procathepsin D in permanent and primary endothelial cell cultures.Glucocorticoid induced expression of glutamine synthetase in hepatoma cells.Obtaining of monoclonal antibodies by means of DNA immunization.Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments.Cell-cell interactions in the regulation of the expression of hepatic enzymes.Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma.Pyruvate attenuates the anti-neoplastic effect of carnosine independently from oxidative phosphorylation.Cloning and expression of the rat BACE1 promoter.Transfection of normal human epidermal keratinocytes with lipid/dna complexes in vitro.Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a-negative tumors.Phenotypic Screen Identifies a Small Molecule Modulating ERK2 and Promoting Stem Cell Proliferation.Comparative in vitro toxicity of seven zinc-salts towards neuronal PC12 cells.The Wnt/β-catenin pathway determines the predisposition- and the efficiency of liver to pancreas reprogramming.Differential and stereoselective in vitro cytotoxicity of eremophilane sesquiterpenes of Petasites hybridus rhizomes in rat hepatocytes.The expression of prolactin and its cathepsin D-mediated cleavage in the bovine corpus luteum vary with the estrous cycleCarnosine selectively inhibits migration of IDH-wildtype glioblastoma cells in a co-culture model with fibroblastsHepatic expression of glutamine synthetase in rats is controlled by STAT5 and TCF transcription factorsReal-time RT-PCR discriminating mRNA encoding osteocalcin from unspecific targetsAntifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic LiverAssessment of ApoC1, LuzP6, C12orf75 and OCC-1 in cystic glioblastoma using MALDI-TOF mass spectrometry, immunohistochemistry and qRT-PCRCarnosine influences transcription via epigenetic regulation as demonstrated by enhanced histone acetylation of the pyruvate dehydrogenase kinase 4 promoter in glioblastoma cellsNon-enzymatic reaction of carnosine and glyceraldehyde-3-phosphate accompanies metabolic changes of the pentose phosphate pathwayCarnosine increases efficiency of temozolomide and irradiation treatment of isocitrate dehydrogenase-wildtype glioblastoma cells in cultureβ-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma PathogenesisThe proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cellsCarnosine's inhibitory effect on glioblastoma cell growth is independent of its cleavageD,L-Methadone does not improve radio- and chemotherapy in glioblastoma in vitroCarnosine inhibits glioblastoma growth independent from PI3K/Akt/mTOR signaling
P50
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P50
description
researcher ORCID ID = 0000-0001-6628-0605
@en
wetenschapper
@nl
name
Frank Gaunitz
@ast
Frank Gaunitz
@en
Frank Gaunitz
@es
Frank Gaunitz
@nl
type
label
Frank Gaunitz
@ast
Frank Gaunitz
@en
Frank Gaunitz
@es
Frank Gaunitz
@nl
prefLabel
Frank Gaunitz
@ast
Frank Gaunitz
@en
Frank Gaunitz
@es
Frank Gaunitz
@nl
P31
P496
0000-0001-6628-0605