about
P688
High-frequency triazole resistance found In nonculturable Aspergillus fumigatus from lungs of patients with chronic fungal diseaseEmergence of azole-resistant aspergillus fumigatus strains due to agricultural azole use creates an increasing threat to human healthSreA-mediated iron regulation in Aspergillus fumigatusEssential gene identification and drug target prioritization in Aspergillus fumigatusSREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatusTriazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatusDiscovery of a HapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossingGenetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in VirulenceResistance to itraconazole in Aspergillus nidulans and Aspergillus fumigatus is conferred by extra copies of the A. nidulans P-450 14alpha-demethylase gene, pdmA.Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanismExploring temporal transcription regulation structure of Aspergillus fumigatus in heat shock by state space model.Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence.Efficacy of posaconazole against three clinical Aspergillus fumigatus isolates with mutations in the cyp51A gene.Differences in interactions between azole drugs related to modifications in the 14-alpha sterol demethylase gene (cyp51A) of Aspergillus fumigatus.Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility.Identification of two different 14-alpha sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other Aspergillus species.First detection of TR46/Y121F/T289A and TR34/L98H alterations in Aspergillus fumigatus isolates from azole-naive patients in Denmark despite negative findings in the environment.Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter.Regulatory circuitry governing fungal development, drug resistance, and disease.Impact of cyp51A mutations on the pharmacokinetic and pharmacodynamic properties of voriconazole in a murine model of disseminated aspergillosisComplementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B.Clonal expansion and emergence of environmental multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR₃₄/L98H mutations in the cyp51A gene in India.Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase.Aspergillus fumigatus strains with mutations in the cyp51A gene do not always show phenotypic resistance to itraconazole, voriconazole, or posaconazole.Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole.Composite survival index to compare virulence changes in azole-resistant Aspergillus fumigatus clinical isolates.Whole-genome comparison of Aspergillus fumigatus strains serially isolated from patients with aspergillosis.Aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on Aspergillus fumigatus azole resistance.Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs.Cryptic species and azole resistance in the Aspergillus niger complex.SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A).Antifungal susceptibilities of Aspergillus fumigatus clinical isolates obtained in Nagasaki, JapanRapid induction of multiple resistance mechanisms in Aspergillus fumigatus during azole therapy: a case study and review of the literature.Evidence for genetic differentiation and variable recombination rates among Dutch populations of the opportunistic human pathogen Aspergillus fumigatus.Genomic Context of Azole Resistance Mutations in Aspergillus fumigatus Determined Using Whole-Genome SequencingHigh prevalence of azole-resistant Aspergillus fumigatus in adults with cystic fibrosis exposed to itraconazole.The T788G mutation in the cyp51C gene confers voriconazole resistance in Aspergillus flavus causing aspergillosis.Resistance to voriconazole due to a G448S substitution in Aspergillus fumigatus in a patient with cerebral aspergillosis.Molecular epidemiology of Aspergillus fumigatus isolates harboring the TR34/L98H azole resistance mechanism.
P921
Q24628838-23BCD2EC-07AB-487F-8644-AB515080CA3FQ26999421-9EEEEFE1-7BAF-4254-865F-988CBAF1CCBBQ27976506-001D05A9-B4DC-43DE-9C87-492A4F2A82D0Q28469156-301F9F37-288C-48FE-A4FE-ACAFAE38B4CBQ28478226-931FB3F5-4FAA-487A-8FCA-1FE84D79E8FAQ28481341-D81ADD0B-FF75-43E5-A473-5E35D5A200B2Q28485433-45861486-3D00-4550-B45A-C262B062318CQ28546712-2014404A-B720-436E-87D5-DA376E8CE825Q30679946-7904EEFD-6D7E-4292-AC0C-5D220703F385Q30853962-1033C9EA-3774-47FD-A1BF-FF87F8992DDDQ33479781-3F401E97-758D-4F2B-AF53-11BFD9AE2A13Q33559702-F340035D-ED17-49B2-99CB-9AC2C792DFA4Q33613758-B5DDD5CE-66E7-4EF7-9470-B6CC7688BD61Q33770230-6F26EC67-CEB5-42BA-A505-8C4CDFE8142FQ33836567-FB33151F-E884-440B-87D0-767F42E60FCDQ33972814-DC6F76A1-7258-496F-AB31-C6547B7A9F47Q34057414-3542D0B2-49DD-4824-9FAC-65A75BF886D5Q34151112-356DD9CA-115C-4CED-BD89-B4FCB898DC05Q34151913-99ED9A4D-1FDD-4ADE-B4EC-488E634E69CAQ34190284-E72638E5-0A50-4214-8A40-641F24F25500Q34290034-07E7F0BD-4FBC-487D-AF8C-93806942D15DQ34290082-7B3E0C29-83F0-48D7-A0E1-0C08568657A5Q34534761-A11974F2-0963-4FE8-9BA7-EFBC95CEA02CQ34823914-6A9F8EA7-8E06-4F41-8FF3-09F44E0BFBD2Q34933141-5B5FB469-F148-4A35-B78F-FB1E86431FE7Q34940421-15200232-1435-4F6F-AEC5-26848E638886Q34977071-7E5DE001-BEFD-4688-B7E4-C4E6A5171E3FQ35036194-66DFFFB2-3D8D-4E16-8A23-8B3982854A9DQ35066763-C42D6200-B2C0-48AD-9D1F-CF26841E5927Q35124469-61FD2F42-74C4-4E50-B87E-3826C34677C5Q35270458-F8F1FB68-BBE8-47EA-8963-812270759438Q35666510-4D5A9B97-6070-4005-B306-39EE9E5484BCQ35666518-F209C8B6-C19E-481A-9B6A-E3EEABA961C0Q35666591-34AECE72-CD4A-40DF-9A08-DD2FB51954ADQ35673582-4F4F12AD-8E09-4A0C-9093-2F295C01E34FQ35676292-28FBD185-48F3-4989-A476-DF1912ADD6FCQ35689428-7AE9A685-0BD2-4ADC-83BD-883F5D4542E2Q35941367-23D5BB58-6C65-4403-A267-676C3129724AQ36118607-AA067981-C1C1-473C-BB09-E7C5EDA99129Q36171422-5A67BC84-F082-4CB2-BFAF-C8EC61DA45C5
P921
description
protein
@id
proteïne in Afu4g06890-T
@nl
protèin
@ace
name
14-alpha sterol demethylase
@en
Afu4g06890-T
@nl
type
label
14-alpha sterol demethylase
@en
Afu4g06890-T
@nl
prefLabel
14-alpha sterol demethylase
@en
Afu4g06890-T
@nl
P279
P31
P3382
Afu4g06890-T