about
Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liverHuman arylacetamide deacetylase is a principal enzyme in flutamide hydrolysisRecommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteinsStructure and Protein-Protein Interactions of Human UDP-GlucuronosyltransferasesChange of drug excretory pathway by CCl4-induced liver dysfunction in ratAn orphan esterase ABHD10 modulates probenecid acyl glucuronidation in human liver.In silico and in vitro approaches to elucidate the thermal stability of human UDP-glucuronosyltransferase (UGT) 1A9.N-Glycosylation plays a role in protein folding of human UGT1A9.Changes in the expression of miRNAs at the pericentral and periportal regions of the rat liver in response to hepatocellular injury: comparison with the changes in the expression of plasma miRNAs.Targeted screen for human UDP-glucuronosyltransferases inhibitors and the evaluation of potential drug-drug interactions with zafirlukast.Cytochrome P450-mediated metabolism of estrogens and its regulation in human.Application of chimeric mice with humanized liver for predictive ADME.Essentials for starting a pediatric clinical study (1): Pharmacokinetics in children.Troglitazone.MicroRNAs from biology to future pharmacotherapy: regulation of cytochrome P450s and nuclear receptors.Toxicological implications of modulation of gene expression by microRNAs.Halothane-induced liver injury is mediated by interleukin-17 in mice.A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development.Allopurinol induces innate immune responses through mitogen-activated protein kinase signaling pathways in HL-60 cells.A novel cell-based assay for the evaluation of immune- and inflammatory-related gene expression as biomarkers for the risk assessment of drug-induced liver injury.Multiparametric assay using HepaRG cells for predicting drug-induced liver injury.CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.Inhibition of cytochrome P450 2C9 expression and activity in vitro by allyl isothiocyanate.Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.Development of mice exhibiting hepatic microsomal activity of human CYP3A4 comparable to that in human liver microsomes by intravenous administration of an adenovirus vector expressing human CYP3A4.Toxicological potential of acyl glucuronides and its assessment.N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity.Evaluation and mechanistic analysis of the cytotoxicity of the acyl glucuronide of nonsteroidal anti-inflammatory drugs.Regulation of cytochrome b5 expression by miR-223 in human liver: effects on cytochrome P450 activities.Epigenetic regulation is a crucial factor in the repression of UGT1A1 expression in the human kidney.Establishment of MDCKII cell monolayer with metabolic activity by CYP3A4 transduced with recombinant adenovirus.Aryl hydrocarbon receptor nuclear translocator in human liver is regulated by miR-24.Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse.MicroRNAs regulate human hepatocyte nuclear factor 4alpha, modulating the expression of metabolic enzymes and cell cycle.PPARα is regulated by miR-21 and miR-27b in human liver.Human paraoxonase 1 is the enzyme responsible for pilocarpine hydrolysis.Interpretation of the effects of protein kinase C inhibitors on human UDP-glucuronosyltransferase 1A (UGT1A) proteins in cellulo.Stimulation of pro-inflammatory responses by mebendazole in human monocytic THP-1 cells through an ERK signaling pathway.Arylacetamide deacetylase is a determinant enzyme for the difference in hydrolase activities of phenacetin and acetaminophen.An in vitro drug-induced hepatotoxicity screening system using CYP3A4-expressing and gamma-glutamylcysteine synthetase knockdown cells.
P50
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P50
description
researcher ORCID ID = 0000-0002-3239-2817
@en
name
Tsuyoshi Yokoi
@ast
Tsuyoshi Yokoi
@en
Tsuyoshi Yokoi
@es
Tsuyoshi Yokoi
@nl
type
label
Tsuyoshi Yokoi
@ast
Tsuyoshi Yokoi
@en
Tsuyoshi Yokoi
@es
Tsuyoshi Yokoi
@nl
prefLabel
Tsuyoshi Yokoi
@ast
Tsuyoshi Yokoi
@en
Tsuyoshi Yokoi
@es
Tsuyoshi Yokoi
@nl
P1153
7201620434
P31
P496
0000-0002-3239-2817