about
Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunateAutomated hypothesis generation based on mining scientific literatureRole for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylationA large-scale evaluation of computational protein function predictionEssential helix interactions in the anion transporter domain of prestin revealed by evolutionary trace analysisThe use of evolutionary patterns in protein annotationMolecular defects in human carbamoy phosphate synthetase I: mutational spectrum, diagnostic and protein structure considerationsProtein function prediction: towards integration of similarity metrics.Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2Accurate protein structure annotation through competitive diffusion of enzymatic functions over a network of local evolutionary similaritiesSeparation of recombination and SOS response in Escherichia coli RecA suggests LexA interaction sitesThe maternal-to-zygotic transition targets actin to promote robustness during morphogenesisIdentification of a candidate therapeutic autophagy-inducing peptideEvolutionary predictions of binding surfaces and interactions.Rapid detection of similarity in protein structure and function through contact metric distancesComposite motifs integrating multiple protein structures increase sensitivity for function prediction.Prediction of enzyme function based on 3D templates of evolutionarily important amino acids.Evolutionary Trace Annotation Server: automated enzyme function prediction in protein structures using 3D templatesUET: a database of evolutionarily-predicted functional determinants of protein sequences that cluster as functional sites in protein structures.Function prediction from networks of local evolutionary similarity in protein structurePrediction and experimental validation of enzyme substrate specificity in protein structures.PyETV: a PyMOL evolutionary trace viewer to analyze functional site predictions in protein complexes.ET viewer: an application for predicting and visualizing functional sites in protein structures.De-orphaning the structural proteome through reciprocal comparison of evolutionarily important structural featuresEvolution-guided discovery and recoding of allosteric pathway specificity determinants in psychoactive bioamine receptors.Evolutionary trace annotation of protein function in the structural proteome.An angiotensin II type 1 receptor activation switch patch revealed through evolutionary trace analysis.Negative feedback in genetic circuits confers evolutionary resilience and capacitance.Evolution: a guide to perturb protein function and networksCharacterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man.Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channelsbeta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.Prediction and redesign of protein-protein interactionsA formal perturbation equation between genotype and phenotype determines the Evolutionary Action of protein-coding variations on fitness.Single nucleotide variations: biological impact and theoretical interpretation.Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptorsAccurate and scalable identification of functional sites by evolutionary tracing.Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence.ETAscape: analyzing protein networks to predict enzymatic function and substrates in Cytoscape.Character and evolution of protein-protein interfaces.
P50
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P50
name
Olivier Lichtarge
@ast
Olivier Lichtarge
@en
Olivier Lichtarge
@es
Olivier Lichtarge
@nl
type
label
Olivier Lichtarge
@ast
Olivier Lichtarge
@en
Olivier Lichtarge
@es
Olivier Lichtarge
@nl
prefLabel
Olivier Lichtarge
@ast
Olivier Lichtarge
@en
Olivier Lichtarge
@es
Olivier Lichtarge
@nl