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Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G{middle dot}C{middle dot}G{middle dot}C tetradHuman telomeres that contain (CTAGGG)n repeats show replication dependent instability in somatic cells and the male germlineCharacterization of terminal deletions at 7q32 and 22q13.3 healed by De novo telomere additionHigh levels of sequence polymorphism and linkage disequilibrium at the telomere of 12q: implications for telomere biology and human evolution.Structural gene encoding human factor XII is located at 5q33-qter.HHV-8-unrelated primary effusion-like lymphoma associated with clonal loss of inherited chromosomally-integrated human herpesvirus-6A from the telomere of chromosome 19q.Principles and recent advances in human DNA fingerprinting.Telomere length maintenance--an ALTernative mechanism.Telomere maintenance in soft tissue sarcomasHuman telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome.Chromosomally Integrated Human Herpesvirus 6: Models of Viral Genome Release from the Telomere and Impacts on Human Health.Deficiency in DNA mismatch repair increases the rate of telomere shortening in normal human cells.Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies.Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA.Inherited Chromosomally Integrated Human Herpesvirus 6 Genomes Are Ancient, Intact, and Potentially Able To Reactivate from Telomeres.Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome.The proterminal regions and telomeres of human chromosomes.Spontaneous mutation rates to new length alleles at tandem-repetitive hypervariable loci in human DNA.Telomere instability detected in sporadic colon cancers, some showing mutations in a mismatch repair gene.The plasticity of human telomeres demonstrated by a hypervariable telomere repeat array that is located on some copies of 16p and 16q.Circulating tumour-derived DNA in metastatic soft tissue sarcoma.The CEPH consortium linkage map of human chromosome 16Isolation of telomere junction fragments by anchored polymerase chain reactionClustering of hypervariable minisatellites in the proterminal regions of human autosomesA DNA marker for human chromosome 8 that detects alleles of differing sizes"Major minisatellite loci" detected by minisatellite clones 33.6 and 33.15 correspond to the cognate loci D1S111 and D7S437The gene for clotting factor 10 is mapped to 13q32----qterNew C-band polymorphism in the White Park cattle of Great BritainAbnormal segregation of alleles in CEPH pedigree DNAs arising from allele loss in lymphoblastoid DNATelomeres and diseaseALT: A Multi-Faceted PhenomenonHuman RAP1 specifically protects telomeres of senescent cells from DNA damage
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Nicola J Royle
@ast
Nicola J Royle
@en
Nicola J Royle
@es
Nicola J Royle
@nl
type
label
Nicola J Royle
@ast
Nicola J Royle
@en
Nicola J Royle
@es
Nicola J Royle
@nl
prefLabel
Nicola J Royle
@ast
Nicola J Royle
@en
Nicola J Royle
@es
Nicola J Royle
@nl
P106
P21
P31
P496
0000-0003-1174-6329