about
The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcriptionFRNK expression promotes smooth muscle cell maturation during vascular development and after vascular injuryMyocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophyNuclear RhoA signaling regulates MRTF-dependent SMC-specific transcription.Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21(Cip1.).Skeletal muscle differentiation and fusion are regulated by the BAR-containing Rho-GTPase-activating protein (Rho-GAP), GRAF1GRAF1 deficiency blunts sarcolemmal injury repair and exacerbates cardiac and skeletal muscle pathology in dystrophin-deficient mice.GRAF1 promotes ferlin-dependent myoblast fusionTransient expression of FRNK reveals stage-specific requirement for focal adhesion kinase activity in cardiac growthFAK regulates cardiomyocyte survival following ischemia/reperfusion.Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignmentFocal adhesion kinase is essential for cardiac looping and multichamber heart formationRegulation of myocardin factor protein stability by the LIM-only protein FHL2Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding.Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth.Focal adhesion kinase regulates smooth muscle cell recruitment to the developing vasculature.Inhibition of Diaphanous Formin Signaling In Vivo Impairs Cardiovascular Development and Alters Smooth Muscle Cell Phenotype.Enhancement of mDia2 activity by Rho-kinase-dependent phosphorylation of the diaphanous autoregulatory domain.Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation.Targeted focal adhesion kinase activation in cardiomyocytes protects the heart from ischemia/reperfusion injuryFormin homology domain-containing protein 1 regulates smooth muscle cell phenotype.PKA-dependent phosphorylation of serum response factor inhibits smooth muscle-specific gene expression.Germline deletion of FAK-related non-kinase delays post-natal cardiomyocyte mitotic arrestSphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors.DNA methylation of a GC repressor element in the smooth muscle myosin heavy chain promoter facilitates binding of the Notch-associated transcription factor, RBPJ/CSL1.Smooth muscle cell-specific transcription is regulated by nuclear localization of the myocardin-related transcription factors.Diaphanous 1 and 2 regulate smooth muscle cell differentiation by activating the myocardin-related transcription factors.
P50
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P50
name
Christopher P Mack
@ast
Christopher P Mack
@en
Christopher P Mack
@nl
type
label
Christopher P Mack
@ast
Christopher P Mack
@en
Christopher P Mack
@nl
prefLabel
Christopher P Mack
@ast
Christopher P Mack
@en
Christopher P Mack
@nl