about
USF1 deficiency activates brown adipose tissue and improves cardiometabolic healthHDL functionality in reverse cholesterol transport--Challenges in translating data emerging from mouse models to human disease.Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDL.Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties.Smooth Muscle Cell Foam Cell Formation, Apolipoproteins, and ABCA1 in Intracranial Aneurysms: Implications for Lipid Accumulation as a Promoter of Aneurysm Wall Rupture.Extracellular modifications of HDL in vivo and the emerging concept of proteolytic inactivation of preβ-HDL.The role of the gut in reverse cholesterol transport--focus on the enterocyte.The mast cell as a pluripotent HDL-modifying effector in atherogenesis: from in vitro to in vivo significance.Phytosterol-mediated inhibition of intestinal cholesterol absorption in mice is independent of liver X receptor.Acute psychological stress accelerates reverse cholesterol transport via corticosterone-dependent inhibition of intestinal cholesterol absorption.Mast cell activation in vivo impairs the macrophage reverse cholesterol transport pathway in the mouse.Association of cholesteryl ester transfer protein with HDL particles reduces its proteolytic inactivation by mast cell chymase.A unique protease-sensitive high density lipoprotein particle containing the apolipoprotein A-I(Milano) dimer effectively promotes ATP-binding Cassette A1-mediated cell cholesterol efflux.Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cellsAcidic extracellular environments strongly impair ABCA1-mediated cholesterol efflux from human macrophage foam cells.Mast cell-dependent proteolytic modification of HDL particles during anaphylactic shock in the mouse reduces their ability to induce cholesterol efflux from macrophage foam cells ex vivo.The impact of gender and serum estradiol levels on HDL-mediated reverse cholesterol transport.Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity.Altered HDL Remodeling and Functionality in Familial Hypercholesterolemia.Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation.Chymase released from hypoxia-activated cardiac mast cells cleaves human apolipoproteinA-I at Tyr192 and compromises its cardioprotective activity.High-density lipoproteins (HDL) are present in stenotic aortic valves and may interfere with the mechanisms of valvular calcification.USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages
P50
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P50
name
Miriam Lee-Rueckert
@ast
Miriam Lee-Rueckert
@en
Miriam Lee-Rueckert
@es
Miriam Lee-Rueckert
@nl
type
label
Miriam Lee-Rueckert
@ast
Miriam Lee-Rueckert
@en
Miriam Lee-Rueckert
@es
Miriam Lee-Rueckert
@nl
prefLabel
Miriam Lee-Rueckert
@ast
Miriam Lee-Rueckert
@en
Miriam Lee-Rueckert
@es
Miriam Lee-Rueckert
@nl