High-capacity, high-affinity uric acid-xanthine permease
about
P688
Genetic and structural validation ofAspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal targetSubtle hydrophobic interactions between the seventh residue of the zinc finger loop and the first base of an HGATAR sequence determine promoter-specific recognition by the Aspergillus nidulans GATA factor AreA.Identification of the substrate recognition and transport pathway in a eukaryotic member of the nucleobase-ascorbate transporter (NAT) familyFungal nucleobase transporters.Understanding transporter specificity and the discrete appearance of channel-like gating domains in transporters.The sequence and binding specificity of UaY, the specific regulator of the purine utilization pathway in Aspergillus nidulans, suggest an evolutionary relationship with the PPR1 protein of Saccharomyces cerevisiae.Sequence and regulation of the uapA gene encoding a uric acid-xanthine permease in the fungus Aspergillus nidulans.The nucleobase-ascorbate transporter (NAT) signature motif in UapA defines the function of the purine translocation pathway.Nitrogen catabolite repression in yeasts and filamentous fungi.A single amino acid change in a pathway-specific transcription factor results in differing degrees of constitutivity, hyperinducibility and derepression of several structural genes.The nature of an initiator constitutive mutation in Aspergillus nidulans.The validity of the Aspergillus nidulans linkage map.A gene coding for the uric acid-xanthine permease of Aspergillus nidulans: inactivational cloning, characterization, and sequence of a cis-acting mutation.Differential physiological and developmental expression of the UapA and AzgA purine transporters in Aspergillus nidulans.Chimeric purine transporters of Aspergillus nidulans define a domain critical for function and specificity conserved in bacterial, plant and metazoan homologues.Mutations in a dispensable region of the UaY transcription factor of Aspergillus nidulans differentially affect the expression of structural genes.Dynamic elements at both cytoplasmically and extracellularly facing sides of the UapA transporter selectively control the accessibility of substrates to their translocation pathway.Transport-dependent endocytosis and turnover of a uric acid-xanthine permease.Substitution F569S converts UapA, a specific uric acid-xanthine transporter, into a broad specificity transporter for purine-related solutes.The oxpA5 mutation of Aspergillus nidulans is an allele of adB, the gene encoding adenylosuccinate synthetase.The AzgA purine transporter of Aspergillus nidulans. Characterization of a protein belonging to a new phylogenetic cluster.Transcription of purine transporter genes is activated during the isotropic growth phase of Aspergillus nidulans conidia.Localisation of several chromosome I genes of Aspergillus nidulans: implications for mitotic recombination.The arrestin-like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad-range and specific signals.Allopurinol and xanthine use different translocation mechanisms and trajectories in the fungal UapA transporter.Convergent evolution and orphan genes in the Fur4p-like family and characterization of a general nucleoside transporter in Aspergillus nidulans.Purification and partial characterization of the xanthine-uric acid transporter (UapA) of Aspergillus nidulans.Specific interdomain synergy in the UapA transporter determines its unique specificity for uric acid among NAT carriers.Cloning and functional characterization of two bacterial members of the NAT/NCS2 family in Escherichia coli.Comparative substrate recognition by bacterial and fungal purine transporters of the NAT/NCS2 family.The Aspergillus nidulans FcyB cytosine-purine scavenger is highly expressed during germination and in reproductive compartments and is downregulated by endocytosis.The nadA gene of Aspergillus nidulans, encoding adenine deaminase, is subject to a unique regulatory pattern.A novel-type substrate-selectivity filter and ER-exit determinants in the UapA purine transporter.Genetic and molecular characterization of a gene encoding a wide specificity purine permease of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes.Expression and purification of a functional uric acid-xanthine transporter (UapA).Mutational Analysis and Modeling Reveal Functionally Critical Residues in Transmembrane Segments 1 and 3 of the UapA TransporterThe first transmembrane segment (TMS1) of UapA contains determinants necessary for expression in the plasma membrane and purine transportLinkage map and locus listGene symbols in Aspergillus nidulansThe purine degradation pathway, genetics, biochemistry and regulation
P921
Q27678557-881B912B-2191-4CFD-BE65-6DA1C6DB6CBCQ33886975-12D70255-7929-4B17-9EB3-4742D22968DAQ34359270-725FEE50-C0CA-434C-9CB0-EB3566B74BB1Q36929037-7742809A-3CCC-4E14-8055-88D3A04FE59CQ38259553-CC537593-931E-4D4D-BEF0-475796F7291DQ38296879-23B374F5-BC85-4C19-BDFA-63A004F3A6DDQ38314433-50CCD2FE-9C80-43CE-B41C-5CDFE109E297Q38325031-64C2ABEC-A82A-4ABD-BB6F-EFE562D65346Q39428356-7247C4A8-3B9E-4125-ABBE-A82751414F36Q40439668-60E74703-AD9E-4B78-AAE5-3EE9DE4F4731Q40902891-90ED1081-56D2-4AFB-9DEA-2D5A0B708F47Q41595329-554C908F-6C39-4B80-92A5-5B01B6A6B42DQ41848775-6A118658-8338-4F08-8585-66C9B605ADE0Q42504623-AD14F417-4251-4053-BC9B-E41CEA4A9F9DQ42648346-02934B29-A4E1-4552-A192-265177718CBDQ42660168-0B87E890-C987-41F5-A2E3-740F05A03969Q43147798-CA4FB6D6-5D08-4398-91F3-353C14ABAA4AQ43225270-210C4C29-9F80-40C9-BBF5-B5A25C819FBBQ43791777-61E18DB6-4D4B-4B78-A5A6-7D1646094FDFQ43865856-23ABA15B-6566-4191-8488-FDD4226F99A7Q44642053-9015575B-80AD-46EE-B98C-272FB8FDB3FEQ44818467-74D2DB7D-2BF0-46BF-9179-E6B8AEE162BFQ45094346-D7A38254-6039-4267-AAF2-3A1B1960074AQ45176872-8DBDD9A8-8799-4E41-84A8-82A5B65980E4Q45737019-03DCF169-34E7-44C0-9FA7-F278987EE070Q46002169-A63C6CBA-0B9C-4982-889F-3BD496DB1407Q46341005-85A340B1-B0E8-4420-B831-580BD3B6EE13Q46388890-2E3A9B40-73AF-49A6-AF47-833E9AD3DDBAQ46646735-56360133-54A9-4D7B-A4AE-5DA8AB9915A1Q46646738-83338510-5D53-44A2-857D-302CDFD5D964Q46667872-26526451-5243-4C23-88D0-54BE7F2C6506Q46869365-428C4C66-1E53-4138-8B20-4D887948F8BBQ46932600-CADB6BFF-0721-40DC-A8BD-BDD2180B97A1Q48074518-E9F23248-CB7F-4D18-B099-2038A43AA29EQ50563826-066765F2-2D33-45EB-B9CD-DFF161936E75Q57247042-209486A2-90A6-4446-A713-0B9E2ABE049EQ57247072-93611FAB-810D-4ACF-BBA4-934F0F49AC8FQ62640320-80CD252E-B8AA-4D11-9040-A4217050DFA7Q62641076-A2A0A4B9-CF6C-4044-AD90-7FA4465680A0Q62643878-55EB6EC1-6D62-4739-87FF-8B25F45A403D
P921
High-capacity, high-affinity uric acid-xanthine permease
description
proteïne in AN6932-T
@nl
name
AN6932-T
@nl
High-capacity, high-affinity uric acid-xanthine permease
@en
type
label
AN6932-T
@nl
High-capacity, high-affinity uric acid-xanthine permease
@en
prefLabel
AN6932-T
@nl
High-capacity, high-affinity uric acid-xanthine permease
@en