about
RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice.Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.Tumor-Suppressor Functions of the TP53 Pathway.An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo.Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis.The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL.How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growthMutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor developmentPHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Brandon J Aubrey
@ast
Brandon J Aubrey
@en
Brandon J Aubrey
@es
Brandon J Aubrey
@nl
type
label
Brandon J Aubrey
@ast
Brandon J Aubrey
@en
Brandon J Aubrey
@es
Brandon J Aubrey
@nl
prefLabel
Brandon J Aubrey
@ast
Brandon J Aubrey
@en
Brandon J Aubrey
@es
Brandon J Aubrey
@nl
P106
P31
P496
0000-0002-1372-3107