about
Essential role of proline isomerization in stefin B tetramer formationAtomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by Formula rather than by phosphoranesNear attack conformers dominate -phosphoglucomutase complexes where geometry and charge distribution reflect those of substrateMetal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix.Structural tightening and interdomain communication in the catalytic cycle of phosphoglycerate kinase.α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction.(19)F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA-Catalyzed GTP HydrolysisAmplification of bifunctional ligands for calmodulin from a dynamic combinatorial library.Cryogenic and laser photoexcitation studies identify multiple roles for active site residues in the light-driven enzyme protochlorophyllide oxidoreductaseSimultaneously enhancing spectral resolution and sensitivity in heteronuclear correlation NMR spectroscopyN-terminal domain of prion protein directs its oligomeric association.Pharmacological chaperone for the structured domain of human prion protein.Structure and dynamics of coxsackievirus B4 2A proteinase, an enyzme involved in the etiology of heart diseaseA bacteriophage capsid protein provides a general amyloid interaction motif (GAIM) that binds and remodels misfolded protein assemblies.A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site.Determinants of DNA-binding specificity of ETS-domain transcription factorsLocation and properties of metal-binding sites on the human prion protein.Folding kinetics of the human prion protein probed by temperature jump.Conformational properties of beta-PrP.Reflections on biocatalysis involving phosphorus.The roughness of the protein energy landscape results in anomalous diffusion of the polypeptide backbone.Solution structure of the helicase-interaction domain of the primase DnaG: a model for helicase activation.A reassessment of copper(II) binding in the full-length prion proteinAssessing the Influence of Mutation on GTPase Transition States by Using X-ray Crystallography, 19 F NMR, and DFT Approaches.Metal Fluorides as Analogues for Studies on Phosphoryl Transfer Enzymes.Real-time pure shift ¹⁵N HSQC of proteins: a real improvement in resolution and sensitivity.Limited Proteolysis Reveals That Amyloids from the 3D Domain-Swapping Cystatin B Have a Non-Native β-Sheet Topology.1H, 15N, 13C backbone resonance assignments of human phosphoglycerate kinase in a transition state analogue complex with ADP, 3-phosphoglycerate and magnesium trifluoride.Modulation of contact order effects in the two-state folding of stefins A and B.1H, 15N, 13C backbone resonance assignments of human soluble catechol O-methyltransferase in complex with S-adenosyl-L-methionine and 3,5-dinitrocatechol.Mapping local structural perturbations in the native state of stefin B (cystatin B) under amyloid forming conditions.Obligate heterodimerization of the archaeal Alba2 protein with Alba1 provides a mechanism for control of DNA packaging.Fast protein motions are coupled to enzyme H-transfer reactions.Effects of domain dissection on the folding and stability of the 43 kDa protein PGK probed by NMR.The residue 129 polymorphism in human prion protein does not confer susceptibility to Creutzfeldt-Jakob disease by altering the structure or global stability of PrPC.Enhanced ligand affinity for receptors in which components of the binding site are independently mobile.A method for the reversible trapping of proteins in non-native conformations.A pulse--radiolysis approach to fast reductive cleavage of a disulfide bond to uncage enzyme activity.The mechanism of amyloid-fibril formation by stefin B: temperature and protein concentration dependence of the rates.Exclusion of the native alpha-helix from the amyloid fibrils of a mixed alpha/beta protein.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Jonathan P Waltho
@ast
Jonathan P Waltho
@en
Jonathan P Waltho
@es
Jonathan P Waltho
@nl
type
label
Jonathan P Waltho
@ast
Jonathan P Waltho
@en
Jonathan P Waltho
@es
Jonathan P Waltho
@nl
prefLabel
Jonathan P Waltho
@ast
Jonathan P Waltho
@en
Jonathan P Waltho
@es
Jonathan P Waltho
@nl
P106
P1153
7004600415
P21
P31
P496
0000-0002-7402-5492