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Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2Structural insights into the Slit-Robo complexCharacterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2Human immunodeficiency virus type 1 activates the classical pathway of complement by direct C1 binding through specific sites in the transmembrane glycoprotein gp41Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanismStructural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switchStructural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitopeThe Serine Protease Domain of MASP-3: Enzymatic Properties and Crystal Structure in Complex with EcotinM-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition moleculesThe role of nanometer-scaled ligand patterns in polyvalent binding by large mannan-binding lectin oligomersGenetic and structural analysis of MBL2 and MASP2 polymorphisms in south-eastern African childrenStructures of parasite calreticulins provide insights into their flexibility and dual carbohydrate/peptide-binding properties.Deciphering the fine details of c1 assembly and activation mechanisms: "mission impossible"?Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor.Structure and activation of the C1 complex of complement: unraveling the puzzle.Structure and functions of the interaction domains of C1r and C1s: keystones of the architecture of the C1 complex.Interaction of C1q and mannan-binding lectin with viruses.The envelope glycoprotein of HIV-1 gp120 and human complement protein C1q bind to the same peptides derived from three different regions of gp41, the transmembrane glycoprotein of HIV-1, and share antigenic homology.HIV-1 rsgp41 depends on calcium for binding of human c1q but not for binding of gp120.Further characterization of the interaction between the C1q subcomponent of human C1 and the transmembrane envelope glycoprotein gp41 of HIV-1.Identification of a cryptic protein kinase CK2 phosphorylation site in human complement protease Clr, and its use to probe intramolecular interaction.Structure and assembly of the catalytic region of human complement protease C1r: a three-dimensional model based on chemical cross-linking and homology modeling.Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner.Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats.Association between the Presence of Autoantibodies Targeting Ficolin-3 and Active Nephritis in Patients with Systemic Lupus ErythematosusStructural and Functional Characterization of a Single-Chain Form of the Recognition Domain of Complement Protein C1q.Assembly of C1 and the MBL- and ficolin-MASP complexes: structural insights.Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S, which Encode Subcomponents C1r and C1s of Complement.Nanobodies targeting mouse/human VCAM1 for the nuclear imaging of atherosclerotic lesions.Structural insights into the recognition properties of human ficolins.Arrangement of the C1 complex of complement.Structure and properties of the Ca(2+)-binding CUB domain, a widespread ligand-recognition unit involved in major biological functions.Functional characterization of the recombinant human C1 inhibitor serpin domain: insights into heparin binding.First Membrane Proximal External Region-Specific Anti-HIV1 Broadly Neutralizing Monoclonal IgA1 Presenting Short CDRH3 and Low Somatic Mutations.Enhancement of Ebola Virus Infection via Ficolin-1 Interaction with the Mucin Domain of GP Glycoprotein.Deciphering Key Residues Involved in the Virulence-promoting Interactions between Streptococcus pneumoniae and Human Plasminogen.C1q: A fresh look upon an old molecule.Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin.Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin.A novel peptide inhibitor of classical and lectin complement activation including ABO incompatibility.
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Nicole Thielens
@ast
Nicole Thielens
@en
Nicole Thielens
@es
Nicole Thielens
@nl
type
label
Nicole Thielens
@ast
Nicole Thielens
@en
Nicole Thielens
@es
Nicole Thielens
@nl
prefLabel
Nicole Thielens
@ast
Nicole Thielens
@en
Nicole Thielens
@es
Nicole Thielens
@nl
P106
P21
P31
P496
0000-0002-7354-0302