about
A blueprint for staging of murine melanocytic lesions based on the Cdk4 ( R24C/R24C ) ::Tyr- NRAS ( Q ) ( 61K ) model.Mouse models for actinic keratosis and squamous cell carcinoma.Three-dimensional modelling for estimation of nevus count and probability of nevus-melanoma progression in a murine model.Plasticity of melanoma in vivo: murine lesions resulting from Trp53, but not Cdk4 or Arf deregulation, display neural transdifferentiation.Keratinocyte Sonic Hedgehog Up-regulation Drives the Development of Giant Congenital Nevi via Paracrine Endothelin-1 Secretion.Melanocyte transformation requires complete loss of all pocket protein function via a mechanism that mitigates the need for MAPK pathway activation.UVB-induced melanocyte proliferation in neonatal mice driven by CCR2-independent recruitment of Ly6c(low)MHCII(hi) macrophages.Hair follicle melanocyte precursors are awoken by ultraviolet radiation via a cell extrinsic mechanism.A mutation in the Cdon gene potentiates congenital nevus development mediated by NRAS(Q61K).Ingenol mebutate field-directed treatment of UVB-damaged skin reduces lesion formation and removes mutant p53 patches.Murine melanomas accelerated by a single UVR exposure carry photoproduct footprints but lack UV signature C>T mutations in critical genes.Clinicopathological characterization of mouse models of melanoma.Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis.Brca1 is involved in establishing murine pigmentation in a p53 and developmentally specific mannerMelanoma susceptibility as a complex trait: genetic variation controls all stages of tumor progressionDifferent genetic mechanisms mediate spontaneous versus UVR-induced malignant melanomaKeratinocyte Cytokine Networks Associated with Human Melanocytic Nevus Development
P50
Q40044674-1512B736-E2E6-4D1C-BF5C-B54C029DAE37Q41621878-D0693FBB-4FCC-4C4F-9F3E-62C36B8BCD1AQ44427640-347C656F-5677-4158-A054-4A7C05D3159EQ44734638-40C81683-8A01-4A7E-A319-5CDFBC0982F8Q50017278-035C2953-0491-43D2-80C9-13EDAC9DC018Q51139885-4B3FB96C-DC0E-4580-B9D3-F5539DA1C161Q51837893-32EE0500-F7A4-4DE6-84B7-0FCD0FAD5CE6Q52943990-5AADBD79-2F6E-4574-80A1-09DE78FF9A2AQ53105517-B3743271-2062-4732-82C0-D0091F4CDF5CQ53184438-862EDB44-ACD0-47DC-B968-8F2127A8E6D2Q53307711-A02D10A9-6038-4D9D-92F9-A3606B2392B4Q53631055-5CB3A1FE-AF2B-40A9-B4E8-BAE39A437BE5Q54655468-AB699973-3A04-4FB3-A76E-8C39D95B485EQ57693306-6D5EE1C7-3C37-4722-BF64-D3373507611EQ57732795-BC8BD4D8-3C27-43AD-A445-84F46931FDA0Q64274553-3F3147C4-0DB1-4D48-874A-06DAA8EBB2AEQ90229296-F8B83264-E68F-4252-9ED1-CC9E88A41110
P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Blake Ferguson
@ast
Blake Ferguson
@en
Blake Ferguson
@es
Blake Ferguson
@nl
type
label
Blake Ferguson
@ast
Blake Ferguson
@en
Blake Ferguson
@es
Blake Ferguson
@nl
prefLabel
Blake Ferguson
@ast
Blake Ferguson
@en
Blake Ferguson
@es
Blake Ferguson
@nl
P106
P31
P496
0000-0002-5643-6976