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The Sec1p/Munc18 protein Vps45p binds its cognate SNARE proteins via two distinct modes.The newly identified yeast GRD genes are required for retention of late-Golgi membrane proteins.Vacuole biogenesis in Saccharomyces cerevisiae: protein transport pathways to the yeast vacuoleTomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocationSyntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cellsRegulated transport of the glucose transporter GLUT4Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c in vitroInsulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanismTyrosine phosphorylation of Munc18c on residue 521 abrogates binding to Syntaxin 4Autoinhibition of SNARE complex assembly by a conformational switch represents a conserved feature of syntaxins.The Sec1/Munc18 protein Vps45 regulates cellular levels of its SNARE binding partners Tlg2 and Snc2 in Saccharomyces cerevisiaeVPS21 controls entry of endocytosed and biosynthetic proteins into the yeast prevacuolar compartment.GLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif.Characterization of VAMP isoforms in 3T3-L1 adipocytes: implications for GLUT4 trafficking.The membrane protein alkaline phosphatase is delivered to the vacuole by a route that is distinct from the VPS-dependent pathway.Sorting of GLUT4 into its insulin-sensitive store requires the Sec1/Munc18 protein mVps45The N-terminal peptide of the syntaxin Tlg2p modulates binding of its closed conformation to Vps45p.SNARE proteins underpin insulin-regulated GLUT4 traffic.Studies of the regulated assembly of SNARE complexes in adipocytes.Arabidopsis Sec1/Munc18 protein SEC11 is a competitive and dynamic modulator of SNARE binding and SYP121-dependent vesicle traffic.BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.Molecular dissection of the Munc18c/syntaxin4 interaction: implications for regulation of membrane trafficking.Endosomal sorting of GLUT4 and Gap1 is conserved between yeast and insulin-sensitive cells.Recombinant expression of Munc18c in a baculovirus system and interaction with syntaxin4.The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion.Alternative routes to the cell surface underpin insulin-regulated membrane trafficking of GLUT4.A role for the syntaxin N-terminus.mVps45 knockdown selectively modulates VAMP expression in 3T3-L1 adipocytes.Homotypic vacuole fusion in yeast requires organelle acidification and not the V-ATPase membrane domain.Proximity Ligation Assay to Study the GLUT4 Membrane Trafficking Machinery.SNARE phosphorylation: a control mechanism for insulin-stimulated glucose transport and other regulated exocytic events.Cellular levels of the syntaxin Tlg2p are regulated by a single mode of binding to Vps45p.The Sec1p/Munc18 (SM) protein, Vps45p, cycles on and off membranes during vesicle transport.Characterization of two distinct binding modes between syntaxin 4 and Munc18cLocalization of a protein A-tagged Kex2 protein to the vacuole of Saccharomyces cerevisiae allows rapid purification of vacuolar membranes
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Nia J Bryant
@ast
Nia J Bryant
@en
Nia J Bryant
@es
Nia J Bryant
@nl
type
label
Nia J Bryant
@ast
Nia J Bryant
@en
Nia J Bryant
@es
Nia J Bryant
@nl
prefLabel
Nia J Bryant
@ast
Nia J Bryant
@en
Nia J Bryant
@es
Nia J Bryant
@nl
P108
P106
P108
P31
P496
0000-0001-7431-3809