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Atomic resolution structures of trypsin provide insight into structural radiation damageSpecific radiation damage can be used to solve macromolecular crystal structuresCrystal structure of alkaline phosphatase from the Antarctic bacterium TAB5The crystal structure of DR2241 from Deinococcus radiodurans at 1.9 A resolution reveals a multi-domain protein with structural similarity to chelatases but also with two additional novel domainsStructural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stabilityHigh-resolution structure of the antibiotic resistance protein NimA fromDeinococcus radioduransBiophysical characterization and mutational analysis of the antibiotic resistance protein NimA from Deinococcus radioduransCrystal Structures of Pseudomonas aeruginosa GIM-1: Active-Site Plasticity in Metallo- -LactamasesCrystal Structure of the Mobile Metallo- -Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the Role of Gln157Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogenLegionella pneumophilaSynthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albuminFunctional and structural studies of a novel cold-adapted esterase from an Arctic intertidal metagenomic libraryStructural and biophysical analysis of interactions between cod and human uracil-DNAN-glycosylase (UNG) and UNG inhibitor (Ugi)Structural and biochemical characterization of VIM-26 shows that Leu224 has implications for the substrate specificity of VIM metallo-β-lactamasesDiscovery of Novel Inhibitor Scaffolds against the Metallo-β-lactamase VIM-2 by Surface Plasmon Resonance (SPR) Based Fragment ScreeningBiochemical characterization and structural analysis of a new cold-active and salt-tolerant esterase from the marine bacterium Thalassospira spScreening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance ScreeningStructural basis of 5-nitroimidazole antibiotic resistance: the crystal structure of NimA from Deinococcus radiodurans.Is radiation damage dependent on the dose rate used during macromolecular crystallography data collection?Cold adapted enzymes.Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface.MutT from the fish pathogen Aliivibrio salmonicida is a cold-active nucleotide-pool sanitization enzyme with unexpectedly high thermostability.The autoinducer synthases LuxI and AinS are responsible for temperature-dependent AHL production in the fish pathogen Aliivibrio salmonicidaFragment-based discovery of inhibitor scaffolds targeting the metallo-β-lactamases NDM-1 and VIM-2.Role of Residues W228 and Y233 in the Structure and Activity of Metallo-β-Lactamase GIM-1.A high-throughput, restriction-free cloning and screening strategy based on ccdB-gene replacement.Structural Insights into TMB-1 and the Role of Residues 119 and 228 in Substrate and Inhibitor Binding.Metallo-β-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding.The structure of the metallo-β-lactamase VIM-2 in complex with a triazolylthioacetamide inhibitor.Discovery of a novel covalent non-β-lactam inhibitor of the metallo-β-lactamase NDM-1.Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436 from Four Patients Involving Six Different Hospitals in Denmark.A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.Exploring the role of L209 residue in the active site of NDM-1 a metallo-β-lactamase.Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophilaOXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-OffsDNA binding with a minimal scaffold: structure-function analysis of Lig E DNA ligases.Supercooled liquid-like solvent in trypsin crystals: implications for crystal annealing and temperature-controlled X-ray radiation damage studiesStructure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysisZN148 - a modular synthetic metallo-β-lactamase inhibitor reverses carbapenem-resistance in Gram-negative pathogens in vivoThe biological assembly of OXA-48 reveals a dimer interface with high charge complementarity and very high affinity
P50
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P50
description
researcher
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wetenschapper
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հետազոտող
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name
Hanna-Kirsti S Leiros
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Hanna-Kirsti S Leiros
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Hanna-Kirsti S Leiros
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Hanna-Kirsti S Leiros
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type
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Hanna-Kirsti S Leiros
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Hanna-Kirsti S Leiros
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Hanna-Kirsti S Leiros
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Hanna-Kirsti S Leiros
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Hanna-Kirsti S Leiros
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Hanna-Kirsti S Leiros
@en
Hanna-Kirsti S Leiros
@es
Hanna-Kirsti S Leiros
@nl
P108
P106
P108
P31
P496
0000-0002-2726-6322