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Identification of the visceral pain pathway activated by noxious colorectal distension in mice.Human enteric neurons: morphological, electrophysiological, and neurochemical identification.4-aminopyridine- and dendrotoxin-sensitive potassium channels influence excitability of vagal mechano-sensitive endings in guinea-pig oesophagus.Cholinergic and nitrergic interneurones in the myenteric plexus of the human colon.Quantification of in vivo colonic motor patterns in healthy humans before and after a meal revealed by high-resolution fiber-optic manometry.Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract.TNBS-induced inflammation modulates the function of one class of low-threshold rectal mechanoreceptors in the guinea pig5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT.Identification of medium/high-threshold extrinsic mechanosensitive afferent nerves to the gastrointestinal tract.Electrophysiological and morphological changes in colonic myenteric neurons from chemotherapy-treated patients: a pilot study.Neuroanatomy and physiology of colorectal function and defaecation: from basic science to human clinical studies.Neural mechanisms of peristalsis in the isolated rabbit distal colon: a neuromechanical loop hypothesis.Extrinsic primary afferent signalling in the gut.Insights into the mechanisms underlying colonic motor patterns.Extrinsic Sensory Innervation of the Gut: Structure and Function.Hydrogen peroxide preferentially activates capsaicin-sensitive high threshold afferents via TRPA1 channels in the guinea pig bladder.Control of intrinsic pacemaker frequency and velocity of colonic migrating motor complexes in mouse.Identification of different functional types of spinal afferent neurons innervating the mouse large intestine using a novel CGRPα transgenic reporter mouse.Conscious voiding during bladder obstruction in guinea pigs correlates with contractile activity of isolated bladders.Damage from dissection is associated with reduced neuro-musclar transmission and gap junction coupling between circular muscle cells of guinea pig ileum, in vitro.Electrophysiological characterization of human rectal afferentsFunction and morphology correlates of rectal nerve mechanoreceptors innervating the guinea pig internal anal sphincter.Mechanisms of mechanotransduction by specialized low-threshold mechanoreceptors in the guinea pig rectum.Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells?Structure-function relationship of sensory endings in the gut and bladder.Pudendal afferent innervation of the guinea pig external anal sphincter.Neurogenic and myogenic motor activity in the colon of the guinea pig, mouse, rabbit, and rat.Functional GABAB receptors are present in guinea pig nodose ganglion cell bodies but not in peripheral mechanosensitive endings.Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells.Rectal intraganglionic laminar endings are transduction sites of extrinsic mechanoreceptors in the guinea pig rectum.Neurochemical coding compared between varicose axons and cell bodies of myenteric neurons in the guinea-pig ileum.The efficacy of treatment of patients with severe constipation or recurrent pseudo-obstruction with pyridostigmine.Rotenone and elevated extracellular potassium concentration induce cell-specific fibrillation of α-synuclein in axons of cholinergic enteric neurons in the guinea-pig ileum.Identifying unique subtypes of spinal afferent nerve endings within the urinary bladder of mice.Peristalsis and propulsion of colonic content can occur after blockade of major neuroneuronal and neuromuscular transmitters in isolated guinea pig colon.Activation of intestinal spinal afferent endings by changes in intra-mesenteric arterial pressure.Regional variation in the neurochemical coding of the myenteric plexus of the human colon and changes in patients with slow transit constipation.Loss of responsiveness of circular smooth muscle cells from the guinea pig ileum is associated with changes in gap junction coupling.Properties of the major classes of mechanoreceptors in the guinea pig bladder.Computer vision-based diameter maps to study fluoroscopic recordings of small intestinal motility from conscious experimental animals.
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P50
description
researcher
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wetenschapper
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հետազոտող
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name
Simon J Brookes
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Simon J Brookes
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Simon J Brookes
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Simon J Brookes
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type
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Simon J Brookes
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Simon J Brookes
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Simon J Brookes
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Simon J Brookes
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Simon J Brookes
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Simon J Brookes
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Simon J Brookes
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Simon J Brookes
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P106
P31
P496
0000-0001-5635-0876