about
A multipurpose vector system for the screening of libraries in bacteria, insect and mammalian cells and expression in vivoDimer-Tetramer Transition between Solution and Crystalline States of Streptavidin and Avidin MutantsStructure and characterization of a novel chicken biotin-binding protein A (BBP-A)A 96-well format for a high-throughput baculovirus generation, fast titering and recombinant protein production in insect and mammalian cells.Preparation of recombinant baculoviruses with the BVboost system.Genetically engineered avidins and streptavidins.Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes.Novel vascular endothelial growth factor D variants with increased biological activityProduction of Hev b5 as a fluorescent biotin-binding tripartite fusion protein in insect cells.Enteroviral proteases: structure, host interactions and pathogenicity.Transduction of vertebrate cells with recombinant baculovirus.Optimized production and purification of Coxsackievirus B1 vaccine and its preclinical evaluation in a mouse model.Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity.Enhanced gene delivery by avidin-displaying baculovirus.Baculovirus capsid display: a novel tool for transduction imaging.Tetravalent single-chain avidin: from subunits to protein domains via circularly permuted avidinsCoxsackievirus counters the host innate immune response by blocking type III interferon expression.Efficient preparation of shuffled DNA libraries through recombination (Gateway) cloning.A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models.A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defence.Chicken avidin-related proteins show altered biotin-binding and physico-chemical properties as compared with avidin.Engineering of chicken avidin: a progressive series of reduced charge mutants.Coxsackievirus B3 VLPs purified by ion exchange chromatography elicit strong immune responses in mice.Human enterovirus 71 strains in the background population and in hospital patients in Finland.Efficient production of active chicken avidin using a bacterial signal peptide in Escherichia coli.Characterization of poultry egg-white avidins and their potential as a tool in pretargeting cancer treatment.Rational design of an active avidin monomer.Chicken avidin-related protein 4/5 shows superior thermal stability when compared with avidin while retaining high affinity to biotin.Construction of a dual chain pseudotetrameric chicken avidin by combining two circularly permuted avidins.Baculovirus-mediated vascular endothelial growth factor-D(ΔNΔC) gene transfer induces angiogenesis in rabbit skeletal muscle.Design and construction of highly stable, protease-resistant chimeric avidins.Novel avidin-like protein from a root nodule symbiotic bacterium, Bradyrhizobium japonicum.A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes.Dual-affinity avidin molecules.A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses.New Coxsackievirus 2Apro and 3Cpro protease antibodies for virus detection and discovery of pathogenic mechanisms.Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes.Mutation of a critical tryptophan to lysine in avidin or streptavidin may explain why sea urchin fibropellin adopts an avidin-like domain.Half-lives of PAHs and temporal microbiota changes in commonly used urban landscaping materials.Construction of hevein (Hev b 6.02) with reduced allergenicity for immunotherapy of latex allergy by comutation of six amino acid residues on the conformational IgE epitopes.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Olli H Laitinen
@ast
Olli H Laitinen
@en
Olli H Laitinen
@es
Olli H Laitinen
@nl
type
label
Olli H Laitinen
@ast
Olli H Laitinen
@en
Olli H Laitinen
@es
Olli H Laitinen
@nl
prefLabel
Olli H Laitinen
@ast
Olli H Laitinen
@en
Olli H Laitinen
@es
Olli H Laitinen
@nl
P106
P1153
7006606746
P31
P496
0000-0002-3751-9952