about
Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesisInsights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangementAutoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and CatalysisExploring the role of conformational heterogeneity in cis-autoproteolytic activation of ThnT.Non-heme iron oxygenases generate natural structural diversity in carbapenem antibioticsAutocatalytic backbone N-methylation in a family of ribosomal peptide natural products.Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated 'Entotheonella' bacteria.Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics.Radical S-adenosyl methionine epimerases: regioselective introduction of diverse D-amino acid patterns into peptide natural products.An Orthogonal D2 O-Based Induction System that Provides Insights into d-Amino Acid Pattern Formation by Radical S-Adenosylmethionine Peptide Epimerases.Manipulation of regulatory genes reveals complexity and fidelity in hormaomycin biosynthesis.Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium.Cobalamin-Dependent C-Methyltransferases From Marine Microbes: Accessibility via Rhizobia Expression.RiPPing apart the rules for peptide natural products.A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bondsGenome mining- and synthetic biology-enabled production of hypermodified peptidesInvestigations into PoyH, a promiscuous protease from polytheonamide biosynthesisA multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheliDistinct Autocatalytic α- N-Methylating Precursors Expand the Borosin RiPP Family of Peptide Natural Products
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Michael F Freeman
@ast
Michael F Freeman
@en
Michael F Freeman
@es
Michael F Freeman
@nl
type
label
Michael F Freeman
@ast
Michael F Freeman
@en
Michael F Freeman
@es
Michael F Freeman
@nl
prefLabel
Michael F Freeman
@ast
Michael F Freeman
@en
Michael F Freeman
@es
Michael F Freeman
@nl
P108
P106
P31
P496
0000-0002-0491-9618