about
The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptorCysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association StudiesA functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolateHeterogeneity of binding sites for ICI 198,615 in human lung parenchymaPharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitroThe leukotriene receptor antagonist montelukast and its possible role in the cardiovascular field.Leukotrienes as mediators of asthma.Transcellular biosynthesis of eicosanoid lipid mediators.In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition.Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure.Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation.Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends.The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.Pharmacogenetics of the G protein-coupled receptors.Functional characterization of E. coli LptC: interaction with LPS and a synthetic ligand.Light on the structure of thromboxane A₂receptor heterodimers.A potential role of PUFAs and COXIBs in cancer chemoprevention.The DRY motif and the four corners of the cubic ternary complex model.A role for inflammatory mediators in heterologous desensitization of CysLT1 receptor in human monocytes.Pharmacological characterization of 2NTX-99 [4-methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide], a potential antiatherothrombotic agent with antithromboxane and nitric oxide donor activity in platelet and vascCysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras.4-Oxystilbene compounds are selective ligands for neuronal nicotinic alphaBungarotoxin receptors.Cysteinyl-leukotrienes in the regulation of beta2-adrenoceptor function: an in vitro model of asthma.Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma.Thromboxane prostanoid receptor in human airway smooth muscle cells: a relevant role in proliferation.Mutational analysis of the highly conserved ERY motif of the thromboxane A2 receptor: alternative role in G protein-coupled receptor signaling.Age-related decline in RACK-1 expression in human leukocytes is correlated to plasma levels of dehydroepiandrosterone.Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents.Working hypothesis on the classification of Cys-leukotriene receptors in airways.Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappaB p65-associated histone acetyltransferase activity.CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation.Impaired thromboxane receptor dimerization reduces signaling efficiency: A potential mechanism for reduced platelet function in vivo.Prolonged in vitro exposure of rat brain slices to adenosine analogues: selective desensitization of adenosine A1 but not A2 receptors.Heterotrimeric G proteins demonstrate differential sensitivity to beta-arrestin dependent desensitization.Lower efficacy: interaction with an inhibitory receptor or partial agonism?DESIGN: computerized optimization of experimental design for estimating Kd and Bmax in ligand binding experiments. I. Homologous and heterologous binding to one or two classes of sites.Nonsteroidal Anti-Inflammatory Drugs: Exploiting Bivalent COXIB/ TP Antagonists for the Control of Cardiovascular Risk.Cysteinyl-leukotriene receptors and cellular signals.Two-Pronged Approach to Anti-Inflammatory Therapy Through the Modulation of the Arachidonic Acid CascadeBoosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology
P50
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P50
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investigador
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onderzoeker
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G.Enrico Rovati
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G.Enrico Rovati
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G.Enrico Rovati
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G.Enrico Rovati
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type
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G.Enrico Rovati
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G.Enrico Rovati
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G.Enrico Rovati
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G.Enrico Rovati
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G.Enrico Rovati
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G.Enrico Rovati
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G.Enrico Rovati
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G.Enrico Rovati
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P106
P1153
7004453023
P21
P31
P496
0000-0002-8788-9783