about
Insertion of a ligand to HER2 in gB retargets HSV tropism and obviates the need for activation of the other entry glycoproteins.{alpha}V{beta}3-integrin routes herpes simplex virus to an entry pathway dependent on cholesterol-rich lipid rafts and dynamin2.Preclinical therapy of disseminated HER-2⁺ ovarian and breast carcinomas with a HER-2-retargeted oncolytic herpesvirus.The Engineering of a Novel Ligand in gH Confers to HSV an Expanded Tropism Independent of gD Activation by Its ReceptorsReplication-competent herpes simplex virus retargeted to HER2 as therapy for high-grade gliomaSystemic delivery of HER2-retargeted oncolytic-HSV by mesenchymal stromal cells protects from lung and brain metastases.Efficacy of HER2 retargeted herpes simplex virus as therapy for high-grade glioma in immunocompetent mice.
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P50
description
investigador
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onderzoeker
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researcher
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name
VALENTINA GATTA
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VALENTINA GATTA
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VALENTINA GATTA
@nl
type
label
VALENTINA GATTA
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VALENTINA GATTA
@en
VALENTINA GATTA
@nl
prefLabel
VALENTINA GATTA
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VALENTINA GATTA
@en
VALENTINA GATTA
@nl
P106
P31
P496
0000-0001-7935-284X