about
An early endosome regulator, Rab5b, is an LRRK2 kinase substrateLRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25G2385R and I2020T Mutations Increase LRRK2 GTPase ActivityDexamethasone induces the expression of LRRK2 and α-synuclein, two genes that when mutated cause Parkinson's disease in an autosomal dominant manner.Increased DJ-1 in urine exosome of Korean males with Parkinson's disease.Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers.Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expressionPhosphorylation of p53 by LRRK2 induces microglial tumor necrosis factor α-mediated neurotoxicity.Oxidized DJ-1 Levels in Urine Samples as a Putative Biomarker for Parkinson's Disease.Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activityG2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responsesEnzyme-linked immunosorbent assays for α-synuclein with species and multimeric state specificitiesUpregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein
P50
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P50
description
investigador
@es
onderzoeker
@nl
researcher
@en
name
Dong Hwan Ho
@ast
Dong Hwan Ho
@en
Dong Hwan Ho
@es
Dong Hwan Ho
@nl
type
label
Dong Hwan Ho
@ast
Dong Hwan Ho
@en
Dong Hwan Ho
@es
Dong Hwan Ho
@nl
prefLabel
Dong Hwan Ho
@ast
Dong Hwan Ho
@en
Dong Hwan Ho
@es
Dong Hwan Ho
@nl
P106
P1153
38661163300
P31
P4012
P496
0000-0003-4938-4108