about
Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARADrosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activityHigh-throughput screening identifies idarubicin as a preferential inhibitor of smooth muscle versus endothelial cell proliferationPhosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of Enabledenabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties.Abl tyrosine kinase and its substrate Ena/VASP have functional interactions with kinesin-1.Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.A high-throughput method to identify novel senescence-inducing compounds.Identification of retinoic acid in a high content screen for agents that overcome the anti-myogenic effect of TGF-beta-1.Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.Enhancing the anticancer properties of cardiac glycosides by neoglycorandomizationMutations in protein-binding hot-spots on the hub protein Smad3 differentially affect its protein interactions and Smad3-regulated gene expressionQuantitative microtiter fibronectin fibrillogenesis assay: use in high throughput screening for identification of inhibitor compounds.Smad4 cooperates with lymphoid enhancer-binding factor 1/T cell-specific factor to increase c-myc expression in the absence of TGF-beta signaling.TGF-beta family factors in Drosophila morphogenesis.Reciprocal Regulation of ERα and ERβ Stability and Activity by Diptoindonesin G.Learning about cancer genes through invertebrate genetics.Drosophila transforming growth factor beta superfamily proteins induce endochondral bone formation in mammalsIdentification of a fibroblast growth factor-binding protein in Drosophila melanogasterDosage-sensitive modifiers of Drosophila abl tyrosine kinase function: prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate.Biochemical characterization of the Drosophila dpp protein, a member of the transforming growth factor beta family of growth factorsMutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domainsLactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.Smad3 induces atrogin-1, inhibits mTOR and protein synthesis, and promotes muscle atrophy in vivo.Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity.Thalassosamide, a Siderophore Discovered from the Marine-Derived Bacterium Thalassospira profundimaris.Can clues to the molecular defects in chronic myelogenous leukemia come from genetic studies on the Abelson tyrosine kinase in fruit flies?Nox2 and Cyclosporine-Induced Renal Hypoxia.Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations.A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling.The Drosophila ras oncogenes: structure and nucleotide sequence.Nucleotide sequences of the Drosophila src and abl homologs: conservation and variability in the src family oncogenes.A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A.Decapentaplegic: a gene complex affecting morphogenesis in Drosophila melanogaster.A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin.Embryonic expression patterns of the Drosophila decapentaplegic gene: separate regulatory elements control blastoderm expression and lateral ectodermal expression.Regulation of cell cycle synchronization by decapentaplegic during Drosophila eye development.Drosophila melanogaster DNA clones homologous to vertebrate oncogenes: evidence for a common ancestor to the src and abl cellular genes.A High-Throughput Screening Strategy to Identify Inhibitors of SSB Protein-Protein Interactions in an Academic Screening FacilityPractical Model Selection for Prospective Virtual Screening
P50
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P50
description
Forscher
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investigador
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研究者
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F M Hoffmann
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F M Hoffmann
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F M Hoffmann
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F M Hoffmann
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F M Hoffmann
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F M Hoffmann
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F M Hoffmann
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F M Hoffmann
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F M Hoffmann
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F M Hoffmann
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F M Hoffmann
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F M Hoffmann
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P31
P496
0000-0002-2770-9656