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The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationshipsEssential role of proline isomerization in stefin B tetramer formationVersatile Loops in Mycocypins Inhibit Three Protease FamiliesStefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleftStructural Basis of Trypsin Inhibition and Entomotoxicity of Cospin, Serine Protease Inhibitor Involved in Defense of Coprinopsis cinerea Fruiting BodiesBivalent Carbohydrate Binding Is Required for Biological Activity of Clitocybe nebularis Lectin (CNL), the N,N'-Diacetyllactosediamine (GalNAc 1-4GlcNAc, LacdiNAc)-specific Lectin from Basidiomycete C. nebularisLysosomal cysteine proteases (cathepsins): promising drug targets.FEM: feature-enhanced map.Codon optimisation is key for pernisine expression in Escherichia coliInterpretation of ensembles created by multiple iterative rebuilding of macromolecular modelsTwo decades of thyroglobulin type-1 domain research.Amyloid fibril formation by human stefins: Structure, mechanism & putative functions.Partial rotational lattice order-disorder in stefin B crystals.Boxes of Model Building and Visualization.The CWB2 Cell Wall-Anchoring Module Is Revealed by the Crystal Structures of the Clostridium difficile Cell Wall Proteins Cwp8 and Cwp6.Comparison of in silico tools for binding site prediction applied for structure-based design of autolysin inhibitors.Free kick instead of cross-validation in maximum-likelihood refinement of macromolecular crystal structures.Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft.The mechanism behind the selection of two different cleavage sites in NAG-NAM polymers.Proline Residues as Switches in Conformational Changes Leading to Amyloid Fibril FormationMAIN software for density averaging, model building, structure refinement and validation.Crystallization and preliminary X-ray crystallographic analysis of the cysteine protease inhibitor clitocypinInhibitory fragment from the p41 form of invariant chain can regulate activity of cysteine cathepsins in antigen presentation.The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis.Different propensity to form amyloid fibrils by two homologous proteins-Human stefins A and B: searching for an explanation.A novel β-trefoil lectin from the parasol mushroom (Macrolepiota procera) is nematotoxic.Application of fragment based virtual screening towards inhibition of bacterial N-acetyglucosaminidaseDiscovery of (phenylureido)piperidinyl benzamides as prospective inhibitors of bacterial autolysin E from Staphylococcus aureusValidation and quality assessment of macromolecular structures using complex network analysisRefined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithromboticsPrimary structure of ammodytoxin C further reveals the toxic site of ammodytoxinImmunological studies of the toxic site in ammodytoxin ACrystallographic determination of thrombin complexes with small synthetic inhibitors as a starting point for the receptor-based design of antithromboticsE-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl groupExpression, purification and assembly of soluble multimeric MHC class II-invariant chain complexesFungal β-trefoil trypsin inhibitors cnispin and cospin demonstrate the plasticity of the β-trefoil fold
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