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The binding of [3H]thienyl cyclohexylpiperidine ([3H]TCP) to the NMDA-phencyclidine receptor complexEffect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time windowEarly postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1.Antiparkinson potential of delta-opioid receptor agonists.Serotonin in Alzheimer-type dementia and other dementing illnesses.A randomized, placebo-controlled pilot trial of the delta opioid receptor agonist AZD2327 in anxious depression.Advancing drug discovery for neuropsychiatric disorders using patient-specific stem cell models.Altered expression of histamine signaling genes in autism spectrum disorder.CNS Target Identification and Validation: Avoiding the Valley of Death or Naive Optimism?From bench to bedside: mGluR2 positive allosteric modulators as medications to treat substance use disorders.Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models.Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy").The neuroprotective actions of chlormethiazole.Neurotransmitters and second messengers in aging and Alzheimer's disease.Derisking Psychiatric Drug Development: The NIMH's Fast Fail Program, A Novel Precompetitive Model.The central nervous system effects of the partial GABA-Aα2,3 -selective receptor modulator AZD7325 in comparison with lorazepam in healthy males.Alzheimer's disease research and development: a call for a new research roadmap.The mGluR2 Positive Allosteric Modulator, AZD8529, and Cue-Induced Relapse to Alcohol Seeking in Rats.Neuroprotective efficacy of AR-A008055, a clomethiazole analogue, in a global model of acute ischaemic stroke and its effect on ischaemia-induced glutamate and GABA efflux in vitro.The interaction of AR-A008055 and its enantiomers with the GABA(A) receptor complex and their sedative, muscle relaxant and anticonvulsant activity.AZD8529, a positive allosteric modulator at the mGluR2 receptor, does not improve symptoms in schizophrenia: A proof of principle study.Attenuation of nicotine-taking and nicotine-seeking behavior by the mGlu2 receptor positive allosteric modulators AZD8418 and AZD8529 in rats.Metabotropic Glutamate Receptors 2 and 3 as Targets for Treating Nicotine Addiction.A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus.Attenuation by chlormethiazole of oedema following focal ischaemia in the cerebral cortex of the rat.Functional benefit from clomethiazole treatment after focal cerebral ischemia in a nonhuman primate species.Brain serotonin receptors in Huntington's disease.Chlormethiazole antagonises seizures induced by N-methyl-DL-aspartate without interacting with the NMDA receptor complex.Effect of chlormethiazole, dizocilpine and pentobarbital on harmaline-induced increase of cerebellar cyclic GMP and tremor.Sites of the neurotoxic action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the macaque monkey include the ventral tegmental area and the locus coeruleus.Neurotransmitter metabolites, enzymes and receptors in experimental scrapie.Studies on the enhancement of 5-hydroxytryptamine-mediated behaviour by chlormethiazole and phenytoin.Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides.Striatal dopamine receptors in Alzheimer-type dementia.Elevation of neuropeptide Y (NPY) in substantia innominata in Alzheimer's type dementia.Studies on neurotransmitter receptor systems in neocortex and hippocampus in senile dementia of the Alzheimer-type.AZD6280, a novel partial γ-aminobutyric acid A receptor modulator, demonstrates a pharmacodynamically selective effect profile in healthy male volunteers.A comparison of [3H]MK-801 and N-[1-(2-thienyl)cyclohexyl]-3,4-[3H]piperidine binding to the N-methyl-D-aspartate receptor complex in human brain.Monoamine metabolism in senile dementia of Alzheimer type.Characterisation of learning and memory deficits following NMDA receptor antagonism.
P50
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