about
Parallel solid-phase synthesis of a small library of linear and hydrocarbon-bridged analogues of VEGF(81-91): potential biological tools for studying the VEGF/VEGFR-1 interaction.TRPV1 modulators: structure-activity relationships using a rational combinatorial approach.Highly functionalized 1,2-diamino compounds through reductive amination of amino acid-derived β-keto estersStrategies for design of non peptide CCK1R agonist/antagonist ligands.De novo designed library of linear helical peptides: an exploratory tool in the discovery of protein-protein interaction modulators."Dipeptoids": from the chemical structure of the endogenous peptide to the design of peptidomimetics.A role for ring-closing metathesis in medicinal chemistry: mimicking secondary architectures in bioactive peptides.Advances in modulating thermosensory TRP channels.Enantioselective synthesis of PPAR (peroxisome proliferator-activated receptors) agonists and antagonists.Transient Receptor Potential Melastatin 8 Channel (TRPM8) Modulation: Cool Entryway for Treating Pain and Cancer.1,3-diphenylpropan-1-ones as allosteric modulators of α7 nACh receptors with analgesic and antioxidant properties.Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain.Optically active 1,3,4,4-tetrasubstituted β-lactams: synthesis and evaluation as tumor cell growth inhibitors.Synthesis, high-throughput screening and pharmacological characterization of β-lactam derivatives as TRPM8 antagonists.Solid-phase synthesis of new Trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers.beta-Turned dipeptoids as potent and selective CCK(1) receptor antagonists.5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1)receptor antagonists: structure-activity relationship studies on the substituent at N2-position.5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1) receptor antagonists: structure-activity relationship studies on the central 1,3-dioxoperhydropyrido[1,2-c]pyrimidine scaffold.Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292.General approach for the stereocontrolled construction of the beta-lactam ring in amino acid-derived 4-alkyl-4-carboxy-2-azetidinones.Exploring solid-phase approaches for the preparation of new beta-lactams from amino acids.Synthesis and anti-HCMV activity of 1-acyl-beta-lactams and 1-acylazetidines derived from phenylalanine.Pharmacological study of IQM-97,423, a potent and selective CCK1 receptor antagonist with protective effect in experimental acute pancreatitis.Disulfide bonds versus TrpTrp pairs in irregular beta-hairpins: NMR structure of vammin loop 3-derived peptides as a case study.From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors.Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.Highly constrained dipeptoid analogues containing a type II' beta-turn mimic as novel and selective CCK-A receptor ligands.Combination of molecular modeling, site-directed mutagenesis, and SAR studies to delineate the binding site of pyridopyrimidine antagonists on the human CCK1 receptor.Conformationally constrained CCK4 analogues incorporating IBTM and BTD beta-turn mimetics.Helical peptides from VEGF and Vammin hotspots for modulating the VEGF-VEGFR interaction.Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity.Disrupting VEGF-VEGFR1 Interaction: De Novo Designed Linear Helical Peptides to Mimic the VEGF13-25 Fragment.2-Oxopyrrolidines and 6-oxoperhydropyrrolo[1,2-a]pyrazines as templates in the search for nonpeptide cholecystokinin ligands.The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecystokinin-A receptor antagonists.Identification, functional gastrointestinal stability and molecular docking studies of lentil peptides with dual antioxidant and angiotensin I converting enzyme inhibitory activities.Ketomethylene and methyleneamino pseudopeptide analogues of insect allatostatins inhibit juvenile hormone and vitellogenin production in the cockroach Blattella germanica.Cyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factor.Recent progress in non-opioid analgesic peptides
P50
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P50
description
Forscher
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investigador
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研究者
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name
R González Muñiz
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R González Muñiz
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R González Muñiz
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R González Muñiz
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type
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R González Muñiz
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R González Muñiz
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R González Muñiz
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R González Muñiz
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prefLabel
R González Muñiz
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R González Muñiz
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R González Muñiz
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R González Muñiz
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P31
P496
0000-0001-8833-4328