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Cationic, linear Au(I) N-heterocyclic carbene complexes: synthesis, structure and anti-mitochondrial activity.Effects of geometric isomerism and anions on the kinetics and mechanism of the stepwise formation of long-range DNA interstrand cross-links by dinuclear platinum antitumor complexes.A new approach to glycan targeting: enzyme inhibition by oligosaccharide metalloshielding.Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols.The trans influence in the modulation of platinum anticancer agent biology: the effect of nitrite leaving group on aquation, reactions with S-nucleophiles and DNA binding of dinuclear and trinuclear compounds.Competitive formation of DNA linkage isomers by a trinuclear platinum complex and the influence of pre-association.Antiangiogenic platinum through glycan targeting.Competitive formation of both long-range 5'-5' and short-range antiparallel 3'-3' DNA interstrand cross-links by a trinuclear platinum complex on binding to a 10-mer duplex.Chimeric platinum-polyamines and DNA binding. Kinetics of DNA interstrand cross-link formation by dinuclear platinum complexes with polyamine linkers.Long range 1,4 and 1,6-interstrand cross-links formed by a trinuclear platinum complex. Minor groove preassociation affects kinetics and mechanism of cross-link formation as well as adduct structure.1 : 2 Adducts of copper(I) halides with 1,2-bis(di-2-pyridylphosphino)ethane: solid state and solution structural studies and antitumour activity.In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake.A gold(I) phosphine complex selectively induces apoptosis in breast cancer cells: implications for anticancer therapeutics targeted to mitochondria.Structure-activity relationships in platinum-acridinylthiourea conjugates: effect of the thiourea nonleaving group on drug stability, nucleobase affinity, and in vitro cytotoxicity.1,2-Bis(di-2-pyridylphosphino-yl)ethane.Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors.Silver diphosphine complexes as antimitochondrial agents.Mitochondrial permeability transition induced by dinuclear gold(I)-carbene complexes: potential new antimitochondrial antitumour agents.Bromide ion binding by a dinuclear gold(I) N-heterocyclic carbene complex: a spectrofluorescence and X-ray absorption spectroscopic study.Gold(i) phosphine compounds as parasite attenuating agents for malaria vaccine and drug development.Structural factors affecting binding of platinum anticancer agents with phospholipids. Influence of charge and phosphate clamp formation.Substitution-Inert Polynuclear Platinum Complexes as Metalloshielding Agents for Heparan Sulfate.Dinuclear Au(i) N-heterocyclic carbene complexes derived from unsymmetrical azolium cyclophane salts: potential probes for live cell imaging applications.Kinetic analysis of the human erythrocyte glyoxalase system using 1H NMR and a computer modelPlatination of A GG Site on Single-Stranded and Double-Stranded forms of A 14-Base Oligonucleotide with Diaqua Cisplatin followed by NMR and HPLC. Influence of the Platinum Ligands and Base Sequence on 5'-G Versus 3'-G Platination SelectivityGlycans as Ligands in Bioinorganic Chemistry. Probing the Interaction of a Trinuclear Platinum Anticancer Complex with Defined Monosaccharide Fragments of Heparan SulfateNMR studies of erythrocytes immobilized in agarose and alginate gelsInteraction of the antitumor Au(I) complex [Au(Ph2P(CH2)2PPh2)2]Cl with human blood plasma, red cells, and lipoproteins: 31P and 1H NMR studiesReaction of cis- and trans-[PtCl2(NH3)2] with reduced glutathione inside human red blood cells, studied by 1H and 15N-[1H] DEPT NMRThe autoxidation and proton dissociation constants of tertiary diphosphines: relevance to biological activityAntimicrobial and anticancer activity of tetrahedral, chelated, diphosphine silver(I) complexes: comparison with copper and goldThe nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drugStructural transitions of a GG-platinated DNA duplex induced by pH, temperature and box A of high-mobility-group protein 1Reactions of cisplatin hydrolytes with methionine, cysteine, and plasma ultrafiltrate studied by a combination of HPLC and NMR techniquesRates of platination of -AG- and -GA- containing double-stranded oligonucleotides: effect of chloride concentrationKinetic and equilibria studies of the aquation of the trinuclear platinum phase II anticancer agent [(trans-PtCl(NH(3))(2))(2)(mu-trans-Pt(NH(3))(2)(NH(2)(CH(2))(6)NH(2))(2))](4+) (BBR3464)Equilibrium and kinetic studies of the aquation of the dinuclear platinum complex [[trans-PtCl(NH3)2]2(mu-NH2(CH2)6NH2)]2+: pKa determinations of aqua ligands via [1H,15N] NMR spectroscopyCompetitive reactions of interstrand and intrastrand DNA-Pt adducts: A dinuclear-platinum complex preferentially forms a 1,4-interstrand cross-link rather than a 1,2 intrastrand cross-link on binding to a GG 14-mer duplexDiversity in guanine-selective DNA binding modes for an organometallic ruthenium arene complexLuminescence studies of the intracellular distribution of a dinuclear gold(I) N-heterocyclic carbene complex
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S J Berners-Price
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S J Berners-Price
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S J Berners-Price
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S J Berners-Price
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S J Berners-Price
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S J Berners-Price
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S J Berners-Price
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S J Berners-Price
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S J Berners-Price
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S J Berners-Price
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P31
P496
0000-0002-7129-0039