miR-125b transcriptionally increased by Nrf2 inhibits AhR repressor, which protects kidney from cisplatin-induced injuryDeleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice.Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones.Multi-layer polymeric implants for sustained release of chemopreventives.Antioxidant and mitochondrial protective effects of oxidized metabolites of oltipraz.[Epidemiologic study of 2 foci of Schistosoma mansoni bilharziasis in Togo (Lama Kara and Kpalimé). Comparative efficacy of oltipraz (RP 35972)]Oltipraz: a laboratory and clinical review.Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model.Hypoxia-inducible factor-1α inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of microRNAs 199a-5p and 20a induction.Involvement of pregnane X receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes.Pharmacokinetics of oltipraz and its major metabolite (RM) in patients with liver fibrosis or cirrhosis: relationship with suppression of circulating TGF-beta1.The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.Quantification of oltipraz using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study in rat plasma.Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice.[The treatment of Schistosomiasis mansoni with RP 35972 (Oltipraz). Preliminary results (author's transl)]Oltipraz therapy in patients with liver fibrosis or cirrhosis: a randomized, double-blind, placebo-controlled phase II trial
P921
Q28395772-71C51DCE-6BAD-4A4C-A547-2375C2481AC1Q33744692-97EAD365-78E0-4A06-8250-D74F2BEA8DEAQ35661008-D63C345C-9C41-4E02-A085-7CC169AC193BQ36292750-16237958-B85F-424B-B4BB-7AF16C0F6EC8Q37679901-87ED3319-F41A-4665-B13E-EB0E237BE216Q38512878-A68CA3F4-4054-4E7D-A624-D6AA38288F9AQ38904291-960F1D99-0318-454B-A8EF-5439335C8C60Q39165020-17D44C9D-FB82-40FE-9608-A11837429C87Q39416515-F12B480A-798A-4011-BFD9-5A52516762D3Q39787071-E8BD117C-A154-4F1F-9F01-43AFE547CBDDQ42954973-BC7354F0-2580-409D-B8CD-958DAC82FFF8Q46868217-9FE63ADB-6975-4828-80E5-372B0EC10907Q53415448-CAFAF346-0AF0-40FA-8D38-638C297F6737Q54397165-5DCA77E6-0FB6-4A92-9EE3-2F6A346F8CA7Q62494946-CD8C9C58-A4C7-406F-BF65-D0B0B855B320Q83861488-5849BD7D-18AD-404E-8C6D-D5156D7A5D89
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
Oltipraz
@fr
Oltipraz
@sh
Oltipraz
@sr
oltipraz
@en
oltipraz
@pt
type
label
Oltipraz
@fr
Oltipraz
@sh
Oltipraz
@sr
oltipraz
@en
oltipraz
@pt
altLabel
4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione
@en
5-(2-Pyrazinyl)-4-methyl-1,2-dithiole-3-thione
@en
Oltipraz
@en
RP 35972
@en
RP-35,972
@en
prefLabel
Oltipraz
@fr
Oltipraz
@sh
Oltipraz
@sr
oltipraz
@en
oltipraz
@pt
P2868
P486
P592
P6366
P661
P662
P683
P117
P1579
P2057
HMDB0041967
P2067
P2275
oltipraz
@en
P231
64224-21-1
P232
P233
CC1=C(SSC1=S)C2=NC=CN=C2
P234
1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3
P235
CKNAQFVBEHDJQV-UHFFFAOYSA-N
P2566
100.058.833