P3781
Trial of Panobinostat in Children With Diffuse Intrinsic Pontine GliomaSafety of LBH589 Alone and in Combination With IV Docetaxel and PrednisoneStudy of Oral LBH589 in Adult Patients With Refractory/Resistant Cutaneous T-Cell LymphomaEfficacy and Safety of LBH589 in Adult Patients With Refractory Chronic Myeloid Leukemia (CML) in Chronic PhaseEfficacy and Safety of LBH589B in Adult Patients With Refractory Chronic Myeloid Leukemia (CML) in Accelerated Phase or Blast Phase (Blast Crisis)Study of Oral LBH589 in Adult Patients With Refractory Cutaneous T-Cell LymphomaSafety of LBH589 Alone and in Combination With Intravenous Docetaxel and PrednisoneEfficacy and Safety of LBH589B in Adult Patients With Multiple MyelomaOral LBH589 in Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL)Panobinostat (LBH589) in Patients With Metastatic MelanomaPhase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic SyndromePhase I Study of Panobinostat + Bortezomib for Relapsed and/or Refractory Mantle Cell Lymphoma (MCL)A Phase II Trial of Panobinostat and Lenalidomide in Patients With Relapsed or Refractory Hodgkin's LymphomaPhase I/II Study With Oral Panobinostat Maintenance Therapy Following Allogeneic Stem Cell Transplantation in Patients With High Risk Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML)A Phase I Study Of Panobinostat/Lenalidomide/Bortezomib/Dex for Relapsed And Relapsed/Refractory Multiple MyelomaA Study to Investigate the Effects of Ketoconazole on LBH589 in Patients With Advanced Solid TumorsPanobinostat and Sorafenib in Treating Patients With Liver Cancer That is Metastatic and/or Cannot Be Removed by SurgeryMelphalan and Panobinostat (LBH589) for the Treatment of Patients With Recurrent Multiple MyelomaPhase II Study of Oral Panobinostat in Adult Patients With Relapsed/Refractory Classical Hodgkin's LymphomaDose-escalating Study of LBH589 in Adult Patients With Advanced Solid TumorsPhase I Study of LBH589 & Erlotinib for Advanced Aerodigestive Tract CancersStudy of the Combination of Panobinostat and Carfilzomib in Patients With Relapsed/Refractory Multiple MyelomaOral Panobinostat Adult Patients DLBCL Relapsed/Refractory Stem Cell Transfusion (ASCT) or Not Eligible for ASCTCombination Therapy of Lenalidomide/Bortezomib/Dexamethasone and Panobinostat in Transplant Eligible New Diagnosed Multiple Myeloma (MM) PatientsStudy of Cisplatin and Pemetrexed in Combination With Panobinostat in Solid TumorsA Study Of Panobinostat In Children With Refractory Hematologic MalignanciesPanobinostat and Carfilzomib in Treating Participants With Relapsed or Refractory Multiple MyelomaSafety and Tolerability Study of RAD001 and LBH589 in All Solid Tumors With Enrichment for EBV Driven TumorsLBH589 (Panobinostat) for the Treatment of MyelofibrosisSafety & Efficacy Study of Oral Panobinostat (LBH589) With Chemotherapy in Patients < 65 Years Old With Acute Myeloid Leukemia (AML)Panobinostat and Fluorouracil Followed By Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer Who Did Not Respond to Previous Fluorouracil-Based ChemotherapyA Phase II Study of Oral Panobinostat (LBH589) and Rituximab to Treat Diffuse Large B Cell Lymphoma (DLBCL)A Study of Panobinostat in Combination With Everolimus for Children and Young Adults With GliomasMTX110 by Convection-Enhanced Delivery in Treating Participants With Newly-Diagnosed Diffuse Intrinsic Pontine GliomaInfusion of Panobinostat (MTX110) Into the Fourth Ventricle or Tumor Resection Cavity in Children and Adults With Recurrent MedulloblastomaPanobinostat Maintenance After HSCT fo High-risk AML and MDSInfusion of Panobinostat (MTX110) Into the Fourth Ventricle in Children and Adults With Recurrent MedulloblastomaPhase I Study of Marizomib + Panobinostat for Children With DIPG
P4844
Phase II study of panobinostat in combination with bevacizumab for recurrent glioblastoma and anaplastic gliomaSynergistic antitumor interactions between MK-1775 and panobinostat in preclinical models of pancreatic cancer.Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia.Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1α destabilizationPhase I/II study of the combination of panobinostat and carfilzomib in patients with relapsed/refractory multiple myeloma.Efficacy of panobinostat and marizomib in acute myeloid leukemia and bortezomib-resistant models.Synergistic Activity of Carfilzomib and Panobinostat in Multiple Myeloma Cells via Modulation of ROS Generation and ERK1/2.Population pharmacokinetics of intravenous and oral panobinostat in patients with hematologic and solid tumors.Targeting breast cancer stem cells in triple-negative breast cancer using a combination of LBH589 and salinomycin.Panobinostat: a review of trial results and future prospects in multiple myeloma.Panobinostat: first global approval.Panobinostat: a novel pan-deacetylase inhibitor for the treatment of relapsed or relapsed and refractory multiple myeloma.An HDAC-Targeted Imaging Probe LBH589-Cy5.5 for Tumor Detection and Therapy Evaluation.The predictive value of ERCC1 and p53 for the effect of panobinostat and cisplatin combination treatment in NSCLC.The histone deacetylase inhibitor panobinostat lowers biomarkers of cardiovascular risk and inflammation in HIV patients.DNA damage response and anti-apoptotic proteins predict radiosensitization efficacy of HDAC inhibitors SAHA and LBH589 in patient-derived glioblastoma cells.A phase I, open-label, multicenter study to evaluate the pharmacokinetics and safety of oral panobinostat in patients with advanced solid tumors and varying degrees of renal functionInfusion of Panobinostat (MTX110) Into the Fourth Ventricle or Tumor Resection Cavity in Children and Adults With Recurrent MedulloblastomaPanobinostat approved for multiple myelomaInfusion of Panobinostat (MTX110) Into the Fourth Ventricle in Children and Adults With Recurrent Medulloblastoma
P921
Q21154358-DD569D37-02E8-479E-8C01-6226945253D6Q21173206-9216EEFD-502C-46EB-A9E4-F19468D02656Q21173207-23014086-853D-4259-9913-C7F58BB18EB4Q21173381-2C653C18-C10F-4724-97B0-8E92AA479164Q21173406-17D675B8-D018-40FF-847B-3182D557F055Q21173427-8F3D2605-9B99-492B-AA5E-DA7C833CEFA3Q5629167-E4311B97-F789-4DBC-A1DC-5CE2741FFEBDQ5773155-6F39B43B-1167-4101-BE33-D00291C12B0C
P129
Q61862202-C128FE43-F777-4FEC-BD10-80FDE4E3FBF8Q61917771-A4B413FB-03FB-4811-9561-00419861D7A4Q61918026-BA3AE4B1-CA35-4FAF-ACA4-D18AE4A0F763Q61921021-7F49C3CB-7D8C-4722-9FCB-DE3822D5EBD3Q61921134-6EF19AA6-E08A-4F11-8E84-D3AAF5302CE6Q61921505-CD913E09-1BD2-4A50-A140-949A0F1DECE1Q61922065-9B6911CE-6E7A-4D60-8875-FEECA7BC40E5Q61924660-142553EF-8C2D-41F1-8505-9737A4C36495Q61937131-C685C847-8198-4065-BCCB-539786C3675EQ61939368-612C2AF4-5474-46D6-8EFC-A5565730F9DEQ61956982-E0AADD75-E450-4B5A-9D7C-AD75495266FFQ61957042-B70DD4C7-0DF7-42C4-A383-55549FDC287CQ61957324-5511186B-28A1-4C38-9C4C-AEE587D333E0Q61967281-88916101-568C-4C11-95F0-06B3EE4646FBQ61975769-80C4A8D0-3651-4EE8-8DD8-F8D81F5126CAQ61980167-30A3A72B-764F-4C18-B5C3-A64E8E2CFE8EQ61980432-7A29D58E-B5F3-4B2F-B91D-E735C1D45F21Q63062499-7C83784B-3305-4991-9D32-D11FCC0740E3Q63062631-40262E42-F5F1-4B0A-8D5D-641A2BE6983EQ63062940-1DDEF06A-0616-4C51-A19E-7D35BDABB73EQ63063033-998E96D7-31AA-4202-9B34-C79D4A4DB2E2Q63319214-E2FA2E55-7B51-4077-9B65-1E5A0F9E2FCCQ63319434-813A5A4C-08D1-4546-9E4D-F0DC2DCBFF33Q63322477-940E7B97-21A6-42EF-BA90-EAD0EECD65C8Q63335781-EFF1AA0F-AD2D-4501-825C-C63B0BB83627Q63336264-7525986F-D5F9-4A68-8EBF-4251BADC8605Q63337733-77527F45-111D-442A-AFF5-4778D4609BA3Q63337783-D0E1B608-685C-429B-9271-77E5046846B1Q63338573-1924A23F-EB9D-42B7-A7D7-1F335E283657Q63340104-9E4D3C12-5682-4B1A-AFF1-06252F565366Q63340435-4414A1D7-01D6-40F1-9294-4C4B1C7C2B8AQ63340457-EEA72E7F-38F9-402E-A6DD-20BA30120C51Q63394703-FBBCD719-97F0-41E6-A6C3-D1009AEE2A29Q63398281-E7F168DB-BAD5-4922-ADB7-9F69A164EF4FQ86261535-819ECDF1-7AAA-4261-9627-0E8A0DEB6D65Q89153482-8D2A0CFA-9F16-450C-81AE-FD19E10292B0Q89154415-94BBA1A7-217C-486D-8B7D-4B1A354B1B48Q90693184-10BF8719-370E-4AB9-A7EB-79EB6555A1B5
P4844
Q30300986-AE1FD6F0-C4B2-4B45-8D8B-3B6122A77167Q34808616-FA982125-E128-429F-B8BD-D5C7814CDE4FQ35018971-82F37E2D-2126-4DEC-8F54-DDEBA06F013DQ35059923-64DE16C7-B2F0-483F-BD19-E2C2B6E79E7EQ35571044-A941B925-9FB2-40F4-B75A-CFD22F482D60Q35572018-D0B862D1-2FA2-477C-B631-AE7D45EFA1FDQ35592352-E82019B6-52FB-4110-AFE0-75935110EF9AQ35603293-BD54CA33-86DE-4BF9-AD3B-691F56C1359AQ36104984-49942B08-CE21-403B-B7C6-7AC403AEEBFAQ38269612-52AADCD3-4CAE-458D-A869-EFD1C1194081Q38403118-F6FCF21F-FE88-43B8-A1F8-C3C137AEFCB9Q38519497-F7C0E063-9A26-45BF-93AD-74B1F655C2E6Q38868985-F4BC8C66-AB4E-4DC5-B26A-B9A3E8B4DF76Q38878715-1D3D33C9-0C57-46EC-A437-24716981650CQ41077095-CE120883-CB1E-4854-90DA-29821EDF9282Q48489618-5F7CA9ED-4138-43E0-ABBF-498E2A7EE1FAQ57696000-301795FA-C1EF-46A3-A69A-4F3804ED6E68Q86261535-25277142-60AC-4BDD-A664-CBD2B8053588Q86980709-932B79E3-3255-4679-8FF5-CA0CAF7AE432Q89154415-2DB99170-F374-4460-A9FA-52735A0A27CC
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
Panobinostat
@de
Panobinostat
@es
Panobinostat
@nl
Panobinostat
@ro
Panobinostat
@sh
Panobinostat
@sr
Panobinostat
@vi
Panobinostatas
@lt
panobinostat
@en
panobinostat
@fr
type
label
Panobinostat
@de
Panobinostat
@es
Panobinostat
@nl
Panobinostat
@ro
Panobinostat
@sh
Panobinostat
@sr
Panobinostat
@vi
Panobinostatas
@lt
panobinostat
@en
panobinostat
@fr
altLabel
(2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylamide
@en
Farydak®
@en
LBH 589
@en
LBH-589
@en
LBH-589
@pt
LBH589
@en
Panobinostat
@en
prefLabel
Panobinostat
@de
Panobinostat
@es
Panobinostat
@nl
Panobinostat
@ro
Panobinostat
@sh
Panobinostat
@sr
Panobinostat
@vi
Panobinostatas
@lt
panobinostat
@en
panobinostat
@fr