about
Future technology insight: mass spectrometry imaging as a tool in drug research and development.Effects of proportions of dietary macronutrients on glucocorticoid metabolism in diet-induced obesity in ratsSimultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometryTissue-specific increases in 11beta-hydroxysteroid dehydrogenase type 1 in normal weight postmenopausal women.Relative adrenal insufficiency in mice deficient in 5α-reductase 1Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case-control study.Central glucocorticoid administration promotes weight gain and increased 11β-hydroxysteroid dehydrogenase type 1 expression in white adipose tissueDehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease.Effects of acute glucocorticoid blockade on metabolic dysfunction in patients with Type 2 diabetes with and without fatty liver5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor.Clinical measurement of steroid metabolism.5α-reductase type 1 modulates insulin sensitivity in men.Increased whole-body and sustained liver cortisol regeneration by 11beta-hydroxysteroid dehydrogenase type 1 in obese men with type 2 diabetes provides a target for enzyme inhibitionMass spectrometry imaging for dissecting steroid intracrinology within target tissues11β-Hydroxysteroid dehydrogenase activity in the brain does not contribute to systemic interconversion of cortisol and cortisone in healthy men.Increased skeletal muscle 11βHSD1 mRNA is associated with lower muscle strength in ageing.Displacement of cortisol from human heart by acute administration of a mineralocorticoid receptor antagonist.The postprandial rise in plasma cortisol in men is mediated by macronutrient-specific stimulation of adrenal and extra-adrenal cortisol productionGlucocorticoids turn over slowly in human adipose tissue in vivoDeletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis.Convergence in insulin resistance between very severely obese and lean women at the end of pregnancy.Tissue production of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 and metabolic disease.5α-Reduced glucocorticoids: a story of natural selection.It takes two to tango: dimerisation of glucocorticoid receptor and its anti-inflammatory functions.Tissue-specific dysregulation of cortisol regeneration by 11βHSD1 in obesity: has it promised too much?5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects.7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type.Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humansGlucocorticoids are lower at delivery in maternal, but not cord blood of obese pregnancies.Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.Lack of regulation of 11beta-hydroxysteroid dehydrogenase type 1 during short-term manipulation of GH in patients with hypopituitarism.Measurement of tamsulosin in human serum by liquid chromatography-tandem mass spectrometry.Increased glucocorticoid production and altered cortisol metabolism in women with mild to moderate Alzheimer's disease.Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity.Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance.Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone.Is there a gender difference in the associations of birthweight and adult hypothalamic-pituitary-adrenal axis activity?Physiological and pathophysiological applications of sensitive ELISA methods for urinary deoxycorticosterone and corticosterone in rodents.Development of a derivatisation method for the analysis of aldehyde modified amino acid residues in proteins by Fourier transform mass spectrometry.Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11beta-hydroxysteroid dehydrogenase type 2.
P50
Q28087460-11FB4BAA-DCC2-45AB-BFF4-E1014440BB7CQ28749253-F771D36F-F1FB-4D05-9CFD-5976AB5E3709Q33463058-41A8A962-F560-4B42-861A-4F77EF885A97Q33521207-25DE8548-49EC-4749-86B5-116328DF4739Q33922259-15D690C3-0FB3-4155-9526-8BF3513A0070Q34159583-07F1E284-2B5D-4A03-B0E0-342E9B39CA16Q34221912-7140FF2B-DB7B-4E34-8240-0A393B4BBF74Q34266753-E86A0E24-6FD2-4C9B-82F2-9D3E5CDA01D5Q34295395-F992E71A-D502-41FC-B1ED-CE908D623C20Q34308738-E31AB822-58A7-4916-9EEB-4796B610502EQ34317482-D1FD1327-E722-4DF9-990E-79828D9069E2Q34396472-27535942-4FDA-45AC-A902-27E7AABE2F18Q34615362-0971E729-9207-4937-B524-64589EB9258FQ35019726-4170931F-FD5C-49A3-BB50-5421D6E19176Q35055047-521C0530-19A0-4B4A-AD71-B448BA817FF9Q35082771-D6192A45-DCE7-46FB-BA18-414F305A51F4Q35358929-B4CC7BB7-CF10-4422-A192-C584A0C5D121Q35358986-8AAA06FC-1D1E-4D9E-90F0-77412E128061Q35376353-7EEE9B94-3824-4489-9D17-9CA8E37C00DDQ35902890-45376494-766F-4FDD-8C2B-76332377C7B7Q36109241-7A8C3EEC-6558-46CC-947C-4FB0845AE9F8Q36674845-BAC157FC-9D0F-434C-91B6-629DDAE4F14DQ37929463-B14BA5CF-1035-4393-B8D8-1FC5DCF28C2BQ38057876-7FC2B821-97B2-4F28-AF21-F78AADEEFBEAQ38202908-E744F370-7A95-4792-93ED-1C92316E7910Q39607144-8F2C5DBC-9619-4E52-97DF-9DFDE29662A9Q39945945-A1365C41-0BD2-41D1-A94A-5066BD1C7688Q41125941-431DB6A8-960A-494C-BC6A-C756D9468373Q41581839-AE280DFC-F69F-4B01-85E9-C3F631066810Q41637060-0C807A19-A8C0-4A3E-AE76-0DB331CB126BQ42062038-2F131D58-D0C3-4604-80D5-3AC413C53F18Q42154616-DDF278A7-8785-4400-A594-6D0CFEF71E0AQ43546713-CB19E7FC-83AF-40E2-987E-A81CFAD8EB82Q44055207-2320A587-C06B-4210-BF90-96E85E4BBAF0Q44238635-957F3609-5133-4856-B3DB-1A2319657699Q45285404-3B306586-CD48-4CE9-B7BA-B782A56C3DF5Q45298892-3F39FF92-D6D6-42F1-A3F9-F82D06E46D2DQ45939886-1A275EF8-DC15-40FB-A8BA-A647B7F1BD58Q46149555-E7E6A315-9903-4155-84BF-C1682E6EE7FAQ46229451-7773FEDE-CEB2-409A-9733-9947D73B83F7
P50
description
researcher
@en
name
R Andrew
@en
R Andrew
@nl
type
label
R Andrew
@en
R Andrew
@nl
prefLabel
R Andrew
@en
R Andrew
@nl
P106
P31
P496
0000-0002-6916-2994