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Mutant feedback-resistant phosphoribosylpyrophosphate synthetase associated with purine overproduction and gout. Phosphoribosylpyrophosphate and purine metabolism in cultured fibroblastsNormal activity of metabolic pathways involved in the formation and utilization of phosphoribosylpyrophosphate in erythrocytes of patients with primary metabolic goutKelley-Seegmiller syndrome due to a unique variant of hypoxanthine-guanine phosphoribosyltransferase: reduced affinity for 5-phosphoribosyl-1-pyrophosphate manifested only at low, physiological substrate concentrationsAbnormal purine and pyrimidine nucleotide content in primary astroglia cultures from hypoxanthine-guanine phosphoribosyltransferase-deficient transgenic miceDecelerated rate of dendrite outgrowth from dopaminergic neurons in primary cultures from brains of hypoxanthine phosphoribosyltransferase-deficient knockout miceThe adenosine-induced mechanism for the acquisition of ischemic tolerance in primary rat neuronal cultures.Recent data on uric acid lithiasis.Allopurinol in the prophylaxis of uric acid stonesImplications of disorders of purine metabolism for the kidney and the urinary tract.A novel point mutation (I137T) in the conserved 5-phosphoribosyl-1-pyrophosphate binding motif of hypoxanthine-guanine phosphoribosyltransferase (HPRTJerusalem) in a variant of Lesch-Nyhan syndrome.Proceedings: Rarity of cystinuria type I among cystinuric Jews of Libyan origin.High frequency of cystinuria among Jews of Libyan origin.Pentose shunt, phosphoribosylpyrophosphate generation and purine-phosphoribosyltransferases in erythrocytes of patients with polycythemia vera.Proceedings: Characterization of purine metabolism in cultured fibroblasts from a gouty family with feedback-resistant phosphoribosylpyrophosphate synthetase.Metabolic cooperation between human fibroblasts with normal and with mutant superactive phosphoribosylpyrophosphate synthetase.Evidence for X-linkage of phosphoribosylpyrophosphate synthetase in man. Studies with cultured fibroblasts from a gouty family with mutant feedback-resistant enzyme.X-linked pattern of inheritance of gout due to mutant feedback-resistant phosphoribosylpyrophosphate synthetase.Regulation of de novo purine synthesis in human and rat tissue: role of oxidative pentose phosphate pathway activity and of ribose-5-phosphate and phosphoribosylpyrophosphate availability.Transfer of resistance to selective conditions from fibroblasts with mutant feedback-resistant phosphoribosylpyrophosphate synthetase to normal cells. A form of metabolic cooperation.Overproduction disease in man due to enzyme feedback resistance mutation. Purine overproduction in gout due to excessive activity of mutant feedback-resistant phosphoribosylpyrophosphate synthetase.Superactivity of phosphoribosylpyrophosphate synthetase, due to feedback resistance, causing purine overproduction and gout.Regulation of de novo purine synthesis in chick liver slices. Role of phosphoribosylpyrophosphate availability and of salvage purine nucleotide synthesis.Kinetic aspects of purine metabolism in cultured fibroblasts. A comparative study of cells from patients overproducing purines due to HGPRT deficiency and PRPP synthetase superactivity.Synthesis and metabolic fate of purine nucleotides in cultured fibroblasts from normal subjects and from purine overproducing mutants.Alterations in purine metabolism in cultured fibroblasts with HGPRT deficiency and with PRPP synthetase superactivity.Metabolic and calcium kinetic studies in idiopathic hypercalciuria.De novo synthesis of purine nucleotides in human peripheral blood leukocytes. Excessive activity of the pathway in hypoxanthine-guanine phosphoribosyltransferase deficiency.De novo synthesis of purine nucleotides and metabolic availability of phosphoribosylpyrophosphate in leukemic leukocytes.Purine nucleotide metabolism in cultured neurons and astroglia from HPRT-deficient knockout mice.[Hereditary renal hypouricemia][Involvement of kidney and urinary tract in pathologic metabolism of purines]Effects of differentiation-inducing agents on purine nucleotide metabolism in an ovarian cancer cell line.Characterization of the alterations in purine nucleotide metabolism in hypoxanthine-guanine phosphoribosyltransferase-deficient rat neuroma cell line.Familial renal hypouricaemia: two additional cases with uric acid lithiasis.Patterns of lactate dehydrogenase isoenzymes 1 and 2 in serum of patients performing an exercise test.Urine xanthine oxidase activity in urinary tract infectionErythrocyte glutathione reductase in gout and in glucose-6-phosphate dehydrogenase deficiency.Familial renal hypouricemia due to isolated tubular defect.Serum xanthine oxidase in jaundice.Total lactate dehydrogenase and its isoenzymes in serum of patients with non-small-cell lung cancer.
P50
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P50
description
forsker
@nb
name
Oded Sperling
@en
Oded Sperling
@nb
Oded Sperling
@nl
type
label
Oded Sperling
@en
Oded Sperling
@nb
Oded Sperling
@nl
prefLabel
Oded Sperling
@en
Oded Sperling
@nb
Oded Sperling
@nl
P106
P2038
Oded_Sperling