about
GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex IDynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus.Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth.Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules.Taking the cell by stealth or storm? Protein transduction domains (PTDs) as versatile vectors for delivery.WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progressionAurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation.cAMP-dependent protein kinase and c-Jun N-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress.c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges.A beacon of hope in stroke therapy-Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies.Loss of miR-223 and JNK Signaling Contribute to Elevated Stathmin in Malignant Pleural Mesothelioma.Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38(MAPK) signalling involves CaMKII inhibition.Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds.The mechanism of heat shock activation of ERK mitogen-activated protein kinases in the interleukin 3-dependent ProB cell line BaF3.WDR62 Regulates Early Neural and Glial Progenitor Specification of Human Pluripotent Stem Cells.The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development.Activation of signal transducer and activator of transcription (STAT) pathways in failing human hearts.Protection against reperfusion injury by 3',4'-dihydroxyflavonol in rat isolated hearts involves inhibition of phospholamban and JNK2.Factors that influence adult neurogenesis as potential therapy.Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration.Flavonols and flavones - protecting against myocardial ischemia/reperfusion injury by targeting protein kinases.Differences in c-Jun N-terminal kinase recognition and phosphorylation of closely related stathmin-family members.Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK.Severe Heart Failure and Early Mortality in a Double-Mutation Mouse Model of Familial Hypertrophic CardiomyopathyIntact Mitochondrial Electron Transport Function is Essential for Signalling by Hydrogen Peroxide in Cardiac MyocytesQuantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell deathStat3 promotes directional cell migration by regulating Rac1 activity via its activator betaPIXMEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesisDoublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filamentsThe association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical developmentPathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament association
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description
researcher
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wetenschapper
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name
D C Ng
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D C Ng
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type
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D C Ng
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D C Ng
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D C Ng
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D C Ng
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P106
P31
P496
0000-0003-4657-159X