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Interleukin-6 regulates pancreatic alpha-cell mass expansionRegenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) ratsInterleukin-1-receptor antagonist in type 2 diabetes mellitusIncreased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK ratLeptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human isletsInterleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.Mechanisms of beta-cell death in type 2 diabetes.Islet inflammation in type 2 diabetes: from metabolic stress to therapy.Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.Pancreatic islet inflammation in type 2 diabetes: from alpha and beta cell compensation to dysfunction.Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes.Cytokine production by islets in health and diabetes: cellular origin, regulation and function.Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes.Targeting 12-lipoxygenase as a novel strategy to combat the effects of inflammation on beta cells in diabetes.Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates.Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase.Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway.IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice.Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide.Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet.Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis.Dipeptidyl peptidase IV inhibition in animal models of diabetes.Glucose-dependent insulinotropic polypeptide (GIP): development of DP IV-resistant analogues with therapeutic potential.Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells.Increased number of islet-associated macrophages in type 2 diabetes.IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction.Insulin inhibits IL-10-mediated regulatory T cell function: implications for obesity.Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1β production and β-cell dysfunction.Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic ControlHypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto–Kakizaki (GK) ratEarly reduction of circulating homocysteine levels in Goto–Kakizaki rat, a spontaneous nonobese model of type 2 diabetesCharacterization of the carboxyl-terminal domain of the rat glucose-dependent insulinotropic polypeptide (GIP) receptor. A role for serines 426 and 427 in regulating the rate of internalization[Interleukin-1 receptor antagonist-treatment of patients with type 2 diabetes]Insulitis in type 2 diabetesIs there a role for the adaptive immune system in pancreatic beta cell failure in type 2 diabetes?TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6
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P50
description
researcher
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wetenschapper
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name
Jan A Ehses
@en
Jan A Ehses
@nl
type
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Jan A Ehses
@en
Jan A Ehses
@nl
prefLabel
Jan A Ehses
@en
Jan A Ehses
@nl
P106
P31
P496
0000-0001-9066-7607