about
A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding proteinStimulation of endogenous GH and interleukin-6 receptors selectively activates different Jaks and Stats, with a Stat5 specific synergistic effect of dexamethasone.New growth hormone receptor exon 9 mutation causes genetic short statureA dominant-negative mutation of the growth hormone receptor causes familial short statureStudies with a growth hormone antagonist and dual-fluorescent confocal microscopy demonstrate that the full-length human growth hormone receptor, but not the truncated isoform, is very rapidly internalized independent of Jak2-Stat5 signaling
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description
researcher
@en
name
Sigward Von Laue
@en
Von Laue S
@nl
type
label
Sigward Von Laue
@en
Von Laue S
@nl
altLabel
Von Laue S
@en
prefLabel
Sigward Von Laue
@en
Von Laue S
@nl
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P31
P496
0000-0002-5229-4712