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Assessment of preferential T-helper 1 or T-helper 2 induction by low molecular weight compounds using the local lymph node assay in conjunction with RT-PCR and ELISA for interferon-gamma and interleukin-4In vitro exposure effects of cyclosporin A and bis(tri-n-butyltin)oxide on lymphocyte proliferation, cytokine (receptor) mRNA expression, and cell surface marker expression in rat thymocytes and splenocytesWound-healing factors secreted by epidermal keratinocytes and dermal fibroblasts in skin substitutes.MUTZ-3 Langerhans cell maturation and CXCL12 independent migration in reconstructed human gingiva.Immune-competent human skin disease models.MUTZ-3 derived Langerhans cells in human skin equivalents show differential migration and phenotypic plasticity after allergen or irritant exposure.CCL5 and CCL20 mediate immigration of Langerhans cells into the epidermis of full thickness human skin equivalents.Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency.Dendritic cell migration assay: a potential prediction model for identification of contact allergens.Autologous full-thickness skin substitute for healing chronic wounds.Inter-laboratory study of the in vitro dendritic cell migration assay for identification of contact allergens.Technical advance: Langerhans cells derived from a human cell line in a full-thickness skin equivalent undergo allergen-induced maturation and migration.Development of a Full-Thickness Human Gingiva Equivalent Constructed from Immortalized Keratinocytes and Fibroblasts.Gingiva Equivalents Secrete Negligible Amounts of Key Chemokines Involved in Langerhans Cell Migration Compared to Skin Equivalents.Determination of the sensitising activity of the rubber contact sensitisers TMTD, ZDMC, MBT and DEA in a modified local lymph node assay and the effect of sodium dodecyl sulfate pretreatment on local lymph node responses.Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure.International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive-capacity.Allergens of permanent hair dyes induces epidermal damage, skin barrier loss and IL-1 α increase in epidermal in vitro model.Assessment of metal sensitizer potency with the reconstructed human epidermis IL-18 assay.Cytokine and chemokine release upon prolonged mechanical loading of the epidermis.A potential in vitro epidermal equivalent assay to determine sensitizer potencyComparison of the skin sensitization potential of 3 red and 2 black tattoo inks using interleukin-18 as a biomarker in a reconstructed human skin model
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P50
description
researcher
@en
name
Spiekstra SW
@nl
Sw W. Spiekstra
@en
type
label
Spiekstra SW
@nl
Sw W. Spiekstra
@en
altLabel
Spiekstra SW
@en
prefLabel
Spiekstra SW
@nl
Sw W. Spiekstra
@en
P106
P31
P496
0000-0002-8178-5318