about
NS3 protease from hepatitis C virus: biophysical studies on an intrinsically disordered protein domainDesign and structure of an equilibrium protein folding intermediate: a hint into dynamical regions of proteinsTherapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imigluceraseRationally designed interfacial peptides are efficient in vitro inhibitors of HIV-1 capsid assembly with antiviral activityAllosteric inhibitors of the NS3 protease from the hepatitis C virusThe intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site.Protein-cation interactions: structural and thermodynamic aspects.Cysteine Mutational Studies Provide Insight into a Thiol-Based Redox Switch Mechanism of Metal and DNA Binding in FurA from Anabaena sp. PCC 7120.On the link between conformational changes, ligand binding and heat capacity.Biophysical Screening for Identifying Pharmacological Chaperones and Inhibitors Against Conformational and Infectious Diseases.Stevia rebaudiana ethanolic extract exerts better antioxidant properties and antiproliferative effects in tumour cells than its diterpene glycoside stevioside.Rescuing compound bioactivity in a secondary cell-based screening by using γ-cyclodextrin as a molecular carrier.A look at ligand binding thermodynamics in drug discovery.Stabilization of penicillin G acylase from Escherichia coli: site-directed mutagenesis of the protein surface to increase multipoint covalent attachment.Shell Cross-Linked Polymeric Micelles as Camptothecin Nanocarriers for Anti-HCV Therapy.A unified framework based on the binding polynomial for characterizing biological systems by isothermal titration calorimetry.Deconvolution analysis for classifying gastric adenocarcinoma patients based on differential scanning calorimetry serum thermograms.Epoxy sepabeads: a novel epoxy support for stabilization of industrial enzymes via very intense multipoint covalent attachment.Epoxy-amino groups: a new tool for improved immobilization of proteins by the epoxy method.Novel bifunctional epoxy/thiol-reactive support to immobilize thiol containing proteins by the epoxy chemistry.Improving the industrial production of 6-APA: enzymatic hydrolysis of penicillin G in the presence of organic solvents.Thermodynamically controlled synthesis of amide bonds catalyzed by highly organic solvent-resistant penicillin acylase derivatives.New cationic exchanger support for reversible immobilization of proteins.Co-aggregation of penicillin g acylase and polyionic polymers: an easy methodology to prepare enzyme biocatalysts stable in organic media.Enantioselective synthesis of phenylacetamides in the presence of high organic cosolvent concentrations catalyzed by stabilized penicillin G acylase. Effect of the acyl donor.Reversible and strong immobilization of proteins by ionic exchange on supports coated with sulfate-dextran.Experimental validation of in silico target predictions on synergistic protein targets.Stabilization of enzymes by multipoint immobilization of thiolated proteins on new epoxy-thiol supports.The histidine phosphocarrier protein, HPr, binds to the highly thermostable regulator of sigma D protein, Rsd, and its isolated helical fragments.Underexposed polar residues and protein stabilization.Studying the Allosteric Energy Cycle by Isothermal Titration CalorimetryMechanism of FMN Binding to the Apoflavodoxin fromHelicobacter pyloriEnzyme structure and function protection from gastrointestinal degradation using enteric coatingsLigand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosisAmphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1)Reversible enzyme immobilization via a very strong and nondistorting ionic adsorption on support-polyethylenimine compositesIncrease in conformational stability of enzymes immobilized on epoxy-activated supports by favoring additional multipoint covalent attachment*Multifunctional epoxy supports: a new tool to improve the covalent immobilization of proteins. The promotion of physical adsorptions of proteins on the supports before their covalent linkageDetermination of protein-protein interactions through aldehyde-dextran intermolecular cross-linkingSemisynthetic peptide-lipase conjugates for improved biotransformations
P50
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P50
description
researcher
@en
wetenschapper
@nl
name
Olga Abian
@en
Olga Abian
@nl
type
label
Olga Abian
@en
Olga Abian
@nl
prefLabel
Olga Abian
@en
Olga Abian
@nl
P106
P31
P496
0000-0001-5664-1729