about
hTERT-immortalized prostate epithelial and stromal-derived cells: an authentic in vitro model for differentiation and carcinogenesisp53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress.Myocardin in tumor suppression and myofibroblast differentiation.Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling.Replication stress in MLL-rearrangementsDNA-damage response in hematopoietic stem cells: an evolutionary trade-off between blood regeneration and leukemia suppression.Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53.Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase.The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation.p53-dependent down-regulation of telomerase is mediated by p21waf1.SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stressp53 mediates density-dependent growth arrest.The murine telomerase catalytic subunit shares the PAb-240 mutant specific epitope of the p53 protein.Erratum: Replication stress in MLL-rearrangements.Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth.p53 is a regulator of macrophage differentiation.Quercetin alters the DNA damage response in human hematopoietic stem and progenitor cells via TopoII- and PI3K-dependent mechanisms synergizing in leukemogenic rearrangements.Replication stress in hematopoietic stem cells in mouse and man.A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation.Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect.Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype.The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA.The role of the C' terminus of murine p53 in the p53/mdm-2 regulatory loop.Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress.Spironolactone inhibits the growth of cancer stem cells by impairing DNA damage responseTranscriptional programs following genetic alterations in p53, INK4A, and H-Ras genes along defined stages of malignant transformationA novel method for detecting the cellular stemness state in normal and leukemic human hematopoietic cells can predict disease outcome and drug sensitivityAn ERG Enhancer-Based Reporter Identifies Leukemia Cells with Elevated Leukemogenic Potential Driven by ERG-USP9X Feed-Forward Regulation
P50
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P50
description
researcher
@en
wetenschapper
@nl
name
Michael Milyavsky
@en
Milyavsky M
@nl
type
label
Michael Milyavsky
@en
Milyavsky M
@nl
altLabel
Milyavsky M
@en
prefLabel
Michael Milyavsky
@en
Milyavsky M
@nl
P106
P31
P496
0000-0002-5083-0809