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Endothelial epigenetics in biomechanical stress: disturbed flow-mediated epigenomic plasticity in vivo and in vitroInsm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3Arterial endothelial methylome: differential DNA methylation in athero-susceptible disturbed flow regions in vivoTranscriptional program of the endocrine pancreas in mice and humans.Maintaining data integrity in microarray data management.MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro.Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves.Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial TranscriptomeCoexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta.Discovery approaches to UPR in athero-susceptible endothelium in vivo.Biofluids, cell mechanics and epigenetics: Flow-induced epigenetic mechanisms of endothelial gene expression.RAD and the RAD Study-Annotator: an approach to collection, organization and exchange of all relevant information for high-throughput gene expression studies.The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5.Propagation of adipogenic signals through an epigenomic transition state.Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophagesDual lineage-specific expression of Sox17 during mouse embryogenesis.Pancreatic Inflammation Redirects Acinar to β Cell Reprogramming.Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis.Regional determinants of arterial endothelial phenotype dominate the impact of gender or short-term exposure to a high-fat diet.Leveraging putative enhancer-promoter interactions to investigate two-way epistasis in Type 2 Diabetes GWAS.Spatial phenotyping of the endocardial endothelium as a function of intracardiac hemodynamic shear stress.A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.Neuron-specific mRNA complexity responses during hippocampal apoptosis after traumatic brain injury.Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral densityLeveraging epigenomics and contactomics data to investigate SNP pairs in GWASEmbracing study heterogeneity for finding genetic interactions in large-scale research consortiaExploration of a diversity of computational and statistical measures of association for genome-wide genetic studiesA comparison of two workflows for regulome and transcriptome-based prioritization of genetic variants associated with myocardial massGenetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human LiverSNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease
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P50
description
researcher
@en
wetenschapper
@nl
name
Elisabetta Manduchi
@en
Elisabetta Manduchi
@nl
type
label
Elisabetta Manduchi
@en
Elisabetta Manduchi
@nl
prefLabel
Elisabetta Manduchi
@en
Elisabetta Manduchi
@nl
P106
P31
P496
0000-0002-4110-3714