about
Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-CRecQ helicase translocates along single-stranded DNA with a moderate processivity and tight mechanochemical couplingRigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motorKinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzymeNonmuscle myosin II exerts tension but does not translocate actin in vertebrate cytokinesis.Engineering Dictyostelium discoideum myosin II for the introduction of site-specific fluorescence probes.Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke.Biological, biochemical, and kinetic effects of mutations of the cardiomyopathy loop of Dictyostelium myosin II: importance of ALA400Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform.Azidoblebbistatin, a photoreactive myosin inhibitor.Emerging complex pathways of the actomyosin powerstroke.Affinity, avidity, and kinetics of target sequence binding to LC8 dynein light chain isoforms.Enzyme kinetics above denaturation temperature: a temperature-jump/stopped-flow apparatus.The HRDC domain of E. coli RecQ helicase controls single-stranded DNA translocation and double-stranded DNA unwinding rates without affecting mechanoenzymatic coupling.Diversity of structural behavior in vertebrate conventional myosins complexed with actin.Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY.Switch 1 mutation S217A converts myosin V into a low duty ratio motorVisualization of human Bloom's syndrome helicase molecules bound to homologous recombination intermediates.A nucleotide-dependent and HRDC domain-dependent structural transition in DNA-bound RecQ helicase.From keys to bulldozers: expanding roles for winged helix domains in nucleic-acid-binding proteins.Recent adaptations of fluorescence techniques for the determination of mechanistic parameters of helicases and translocases.Streamlined determination of processive run length and mechanochemical coupling of nucleic acid motor activities.Mechanism of action of myosin X, a membrane-associated molecular motor.Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains.Processive translocation mechanism of the human Bloom's syndrome helicase along single-stranded DNA.Myosin and tropomyosin stabilize the conformation of formin-nucleated actin filamentsMechanism of RecQ helicase mechanoenzymatic coupling reveals that the DNA interactions of the ADP-bound enzyme control translocation run terminations.The dynamics of the relay loop tryptophan residue in the Dictyostelium myosin motor domain and the origin of spectroscopic signals.Analysis of nucleotide binding to Dictyostelium myosin II motor domains containing a single tryptophan near the active site.Myosin cleft movement and its coupling to actomyosin dissociation.Myosin V from Drosophila reveals diversity of motor mechanisms within the myosin V family.Human myosin Vc is a low duty ratio, nonprocessive molecular motor.Unrevealed part of myosin's powerstroke accounts for high efficiency of muscle contraction.Human RAD51 rapidly forms intrinsically dynamic nucleoprotein filaments modulated by nucleotide binding state.Functional fine-tuning between bacterial DNA recombination initiation and quality control systems.Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological PotentialLigand entry in human ileal bile acid-binding protein is mediated by histidine protonationSelective perturbation of the myosin recovery stroke by point mutations at the base of the lever arm affects ATP hydrolysis and phosphate releaseHomology sensing via non-linear amplification of sequence-dependent pausing by RecQ helicaseLive cell superresolution-structured illumination microscopy imaging analysis of the intercellular transport of microvesicles and costimulatory proteins via nanotubes between immune cells
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description
researcher ORCID ID=0000-0002-1200-4741
@en
name
Mihály Kovács
@en
Mihály Kovács
@nl
type
label
Mihály Kovács
@en
Mihály Kovács
@nl
prefLabel
Mihály Kovács
@en
Mihály Kovács
@nl
P106
P31
P496
0000-0002-1200-4741