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Structural basis for the rational design of new anti-Brucella agents: the crystal structure of the C366S mutant of L-histidinol dehydrogenase from Brucella suisThe glutamic acid decarboxylase system of the new species Brucella microti contributes to its acid resistance and to oral infection of mice.Glutamate decarboxylase-dependent acid resistance in Brucella spp.: distribution and contribution to fitness under extremely acidic conditions.Identification and isolation of Brucella suis virulence genes involved in resistance to the human innate immune system.RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant of In vivo Brucella suis Pathogenicity.Characterization of Brucella suis clpB and clpAB mutants and participation of the genes in stress responsesSecretion of listeriolysin by Brucella suis inhibits its intramacrophagic replication.Analysis of the behavior of eryC mutants of Brucella suis attenuated in macrophages.Differential use of the two high-oxygen-affinity terminal oxidases of Brucella suis for in vitro and intramacrophagic multiplication.The intramacrophagic environment of Brucella suis and bacterial response.The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cellFrom the discovery of the Malta fever's agent to the discovery of a marine mammal reservoir, brucellosis has continuously been a re-emerging zoonosis.Requirement of norD for Brucella suis virulence in a murine model of in vitro and in vivo infection.Quantitative analysis of the Brucella suis proteome reveals metabolic adaptation to long-term nutrient starvationOxo- and thiooxo-imidazo[1,5-c]pyrimidine molecule library: beyond their interest in inhibition of Brucella suis histidinol dehydrogenase, a powerful protection tool in the synthesis of histidine analogues.Yersinia enterocolitica impairs activation of transcription factor NF-kappaB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production.Global Rsh-dependent transcription profile of Brucella suis during stringent response unravels adaptation to nutrient starvation and cross-talk with other stress responses.Brucella spp. of amphibians comprise genomically diverse motile strains competent for replication in macrophages and survival in mammalian hosts.Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen.Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.The Glutaminase-Dependent System Confers Extreme Acid Resistance to New Species and Atypical Strains of Brucella.Montpellier infectious diseases (MID): 1st annual meeting (2011).Inhibition of beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anionsA new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growthThe stringent response mediator Rsh is required for Brucella melitensis and Brucella suis virulence, and for expression of the type IV secretion system virBBrucella suis histidinol dehydrogenase: synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazideAntimicrobials: targeting virulence genes necessary for intracellular multiplicationThe virB operon is essential for lethality of Brucella microti in the Balb/c murine model of infectionAnti-virulence strategy against Brucella suis: synthesis, biological evaluation and molecular modeling of selective histidinol dehydrogenase inhibitorsInhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moietyN-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrasesLethality of Brucella microti in a murine model of infection depends on the wbkE gene involved in O-polysaccharide synthesis
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P50
description
researcher
@en
name
S Köhler
@en
S Köhler
@nl
type
label
S Köhler
@en
S Köhler
@nl
prefLabel
S Köhler
@en
S Köhler
@nl
P106
P31
P496
0000-0002-3857-3088