about
Structural characterization of a beta-diketone hydrolase from the cyanobacterium Anabaena sp. PCC 7120 in native and product-bound forms, a coenzyme A-independent member of the crotonase suprafamilyStructure of mouse IP-10, a chemokineCrystal structure of vascular endothelial growth factor-B in complex with a neutralising antibody Fab fragmentHighly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl templateDesign, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's diseaseMultiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)Identification and Investigation of Novel Binding Fragments in the Fatty Acid Binding Protein 6 (FABP6)Structure of 6-oxo camphor hydrolase H122A mutant bound to its natural product, (2S,4S)-alpha-campholinic acid: mutant structure suggests an atypical mode of transition state binding for a crotonase homologLead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitors.Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.Crystallization of RusA Holliday junction resolvase from Escherichia coli.The 1.8 A resolution structure of hydroxycinnamoyl-coenzyme A hydratase-lyase (HCHL) from Pseudomonas fluorescens, an enzyme that catalyses the transformation of feruloyl-coenzyme A to vanillin.Crystallization and quaternary structure analysis of an Lrp-like regulatory protein from the hyperthermophile Pyrococcus furiosusDevelopment and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor
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description
researcher
@en
name
P M Leonard
@en
P M Leonard
@nl
type
label
P M Leonard
@en
P M Leonard
@nl
prefLabel
P M Leonard
@en
P M Leonard
@nl
P106
P31
P496
0000-0002-2988-5557