about
Enzyme Tunnels and Gates As Relevant Targets in Drug Design.Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease.Multifunctional iron-chelators with protective roles against neurodegenerative diseases.Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors.Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors.A family of hydroxypyrone ligands designed and synthesized as iron chelators.N-Carboxyalkyl derivatives of 3-hydroxy-4-pyridinones: synthesis, complexation with Fe(III), Al(III) and Ga(III) and in vivo evaluation.Alkylaryl-amino derivatives of 3-hydroxy-4-pyridinones as aluminium chelating agents with potential clinical application.Iminodiacetyl-hydroxamate derivatives as metalloproteinase inhibitors: equilibrium complexation studies with Cu(II), Zn(II) and Ni(II).Searching for new aluminium chelating agents: a family of hydroxypyrone ligands.Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.Catalytic Cycle of Haloalkane Dehalogenases Toward Unnatural Substrates Explored by Computational Modeling.Impact of the access tunnel engineering on catalysis is strictly ligand-specific.Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitorsCAVER Analyst 2.0: analysis and visualization of channels and tunnels in protein structures and molecular dynamics trajectoriesMultitemplate Alignment Method for the Development of a Reliable 3D-QSAR Model for the Analysis of MMP3 InhibitorsNew tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic propertiesCarbonic anhydrase inhibitors: Inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moietiesA novel tripodal tris-hydroxypyrimidinone sequestering agent for trivalent hard metal ions: synthesis, complexation and in vivo studiesComputational Study of Protein-Ligand Unbinding for Enzyme EngineeringA new bis-3-hydroxy-4-pyrone as a potential therapeutic iron chelating agent. Effect of connecting and side chains on the complex structures and metal ion selectivityA gallium complex with a new tripodal tris-hydroxypyridinone for potential nuclear diagnostic imaging: solution and in vivo studies of 67Ga-labeled speciesDesign, synthesis and molecular modeling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitorsNMDA Receptor Opening and Closing-Transitions of a Molecular Machine Revealed by Molecular DynamicsCaverDock: a molecular docking-based tool to analyse ligand transport through protein tunnels and channelsCaverDock: A Novel Method for the Fast Analysis of Ligand Transport
P50
Q36221405-64C7E984-C7AE-4304-8B87-CA32A205CCD0Q39139506-A400F736-9EB6-4243-88AF-16C25060220CQ39181472-7C1BA59E-03CD-4FAE-AA96-4D017AF4BD94Q41740499-17AD3200-69AA-4BCA-9985-5048BCD40993Q42725801-0F4233CC-D182-4ADF-9C63-C905CBD25323Q43061214-F5EFE861-2064-4AF0-B9B0-2EB9F4E5A211Q43972283-16996F88-FA12-4F93-808E-B3E9199B5E9CQ44136296-1E9B5351-E9C5-42B0-9C23-119CD78735DBQ44595046-76459896-65D0-41A9-AA26-F3234306D219Q44624696-FA4D86B7-D7BF-47D3-9A8F-81B2F7498995Q44703022-ECDC0A1F-CD21-4429-82E3-20CDBF9368ACQ46216047-5D744ECE-0C25-42C8-9152-70391ABDA89DQ48058018-2AC3D9B8-24E6-4923-A14B-2556E85BC80FQ52686497-E3D2025D-A1F6-48F5-8E13-69EE33278103Q56933230-F67F5326-8C12-4110-9B83-0306B2410C21Q57461514-12EBB1C1-0433-4720-827E-CE5410F0E151Q58308201-727C2F1A-A162-4A81-8212-0154A11E07BBQ58374529-9F5FD1A6-8240-463E-A062-8E0003811B93Q58863260-FF6FDBC4-39E8-4543-8FD3-D3F1D11F6A1CQ59166652-75AA1509-06C2-4DD1-ACFF-6EBAF8349088Q60916201-6BFC24A5-D304-4633-832C-7CBFABC3EBEAQ62846872-C8E11483-77F0-4AAE-A492-0B2BD2C52173Q63197554-7BDB092B-12F3-4CC9-A3B5-8017E314FF06Q80020065-BFBD54AE-63E3-4CCB-871F-4C93577E99BBQ90381145-9703686B-5F2D-4B85-8FB4-D9039BFF02F1Q91937609-8143CB0C-D0F9-4190-B967-86ED0CAD1266Q92743995-71DD8CCC-D199-489C-BA55-0DAF504B6E59
P50
description
researcher
@en
name
Sérgio Marques
@en
Sérgio Marques
@nl
type
label
Sérgio Marques
@en
Sérgio Marques
@nl
prefLabel
Sérgio Marques
@en
Sérgio Marques
@nl
P106
P31
P496
0000-0002-6281-7505